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Cited by 82Tactile and Sensory InteractionsMotor Control and AdaptationMultisensory perception and integration

Circuits in the rodent brainstem that control whisking in concert with other orofacial motor actions

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McElvain, Lauren E., Friedman, Beth, Karten, Harvey J., Svoboda, Karel, Wang, Fan, Deschênes, Martin, Kleinfeld, David·2018·Neuroscience
DOI 10.1016/j.neuroscience.2017.08.034PMC PMC5849401
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Abstract

The world view of rodents is largely determined by sensation on two length scales. One is within the animal's peri-personal space; sensorimotor control on this scale involves active movements of the nose, tongue, head, and vibrissa, along with sniffing to determine olfactory clues. The second scale involves the detection of more distant space through vision and audition; these detection processes also impact repositioning of the head, eyes, and ears. Here we focus on orofacial motor actions, primarily vibrissa-based touch but including nose twitching, head bobbing, and licking, that control sensation at short, peri-personal distances. The orofacial nuclei for control of the motor plants, as well as primary and secondary sensory nuclei associated with these motor actions, lie within the hindbrain. The current data support three themes: First, the position of the sensors is determined by the summation of two drive signals, i.e., a fast rhythmic component and an evolving orienting component. Second, the rhythmic component is coordinated across all orofacial motor actions and is phase-locked to sniffing as the animal explores. Reverse engineering reveals that the preBötzinger inspiratory complex provides the reset to the relevant premotor oscillators. Third, direct feedback from somatosensory trigeminal nuclei can rapidly alter motion of the sensors. This feedback is disynaptic and can be tuned by high-level inputs. A holistic model for the coordination of orofacial motor actions into behaviors will encompass feedback pathways through the midbrain and forebrain, as well as hindbrain areas.

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  • Cortico-fugal and cortico-thalamo-cortical organization is also mainly ipsilateral and known to form feedback control loops.

    “Similarly, cortico-fugal (61, 62) and cortico-thalamo-cortical (57, 58) organization is also mainly ipsilateral and known to form feedback control loops.”

    From Neural correlates of perceptual decision-making in the primary somatosensory cortex (2026) · cites this paper as [62]

    The “Corticofugal pathways” section (page unavailable) describes descending cortical projections as part of a feedback loop controlling whisker movement. Our copy does not say that these pathways are mainly ipsilateral; a search for “ipsilateral” found no such statement in the paper’s discussion. The corticothalamic part of the citing sentence has separate citations, so this verdict concerns the corticofugal attribution. (LLM, conf=0.84)

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Authors
McElvain, L. E., Friedman, B., Karten, H. J., Svoboda, K., Wang, F., Deschênes, M., & Kleinfeld, D.
Affiliations
  • University of California San Diego (US)
  • Howard Hughes Medical Institute (US)
  • Duke Medical Center (US)
  • Université Laval (CA)
Corresponding author
Kleinfeld, David
ORCID
Venue
Neuroscience
Publisher
Elsevier BV
Published
2018-01
Volume
368
Pages
152-170
ISSN
0306-4522 (ISSN-L)
DOI
10.1016/j.neuroscience.2017.08.034
PMC
PMC5849401
OpenAlex
W2748431171
Cited by
82
References
238
Citations by year
2026: 4 · 2025: 7 · 2024: 10 · 2023: 4 · 2022: 7 · 2021: 7 · 2020: 9 · 2019: 27 · 2018: 6 · 2017: 1
FWCI
1.32
Type
journal article
Language
en
Open access
Licence
Locations
  • Neuroscience (acceptedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
  • eScholarship (California Digital Library) (submittedVersion)
Funders
  • National Institute of Neurological Disorders and Stroke (NS0905905, NS101441, NS058668, NS077986)
  • Canadian Institutes of Health Research (MT-5877)
  • Howard Hughes Medical Institute
  • Tourette Association of America
  • National Institute of Mental Health (MH085499)
  • National Science Foundation (EAGER – 2144GA)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Tactile and Sensory Interactions
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Motor Control and Adaptation
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Multisensory perception and integration
Keywords
whisking, orofacial motor control, vibrissa, peripersonal space, head bobbing, licking behavior, pre-Bötzinger complex, respiratory rhythm, phase locking, sniffing, sensorimotor coordination
MeSH terms
Animals, Behavior, Animal, Brain Stem, Motor Activity, Mouth, Neural Pathways, Rodentia, Sensation, Vibrissae, Touch Perception, Facial Nucleus

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