Calcium Signaling in Neurons and Glial Cells: Role of Cav1 channels
Abstract
Calcium (Ca 2+ ) is an essential component in intracellular signaling of brain cells, and its control mechanisms are of great interest in biological systems. Ca 2+ can signal differently in neurons and glial cells using the same intracellular pathways or cell membrane structural components. These types of machinery are responsible for entry, permanence, and removal of Ca 2+ from the cellular environment and are of vital importance for brain homeostasis. This review highlights the importance of Ca 2+ in neuronal and glial cell physiology as well as aspects of learning, memory, and Alzheimer's disease, focusing on the involvement of L-type voltage-gated Ca 2+ channels.
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Calcium enters neurons primarily through voltage-sensitive calcium (CaV) channels, ionotropic glutamate receptors, and transient receptor potential channels.
“Calcium enters neurons primarily through voltage-sensitive calcium (CaV) channels, ionotropic glutamate receptors, and transient receptor potential channels79,91.”
From CYFIP1 governs the development of cortical axons by modulating calcium availability (2025) · cites this paper as [91]
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References 227 · Cited by 34
- Authors
- Alves, V. S., Alves-Silva, H. S., Orts, D. J. B., Ribeiro-Silva, L., Arcisio-Miranda, M., & Oliveira, F. A.
- Affiliations
- Universidade Federal do ABC (BR)
- Universidade Federal de São Paulo (BR)
- Carleton University (CA)
- Venue
- Neuroscience
- Publisher
- Elsevier BV
- Published
- 2019-11
- Volume
- 421
- Pages
- 95-111
- ISSN
- 0306-4522 (ISSN-L)
- OpenAlex
- W2984556359
- Cited by
- 34
- References
- 227
- Citations by year
- 2026: 5 · 2025: 11 · 2024: 5 · 2023: 2 · 2022: 6 · 2021: 2 · 2020: 3
- FWCI
- 0.24
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Fundação de Amparo à Pesquisa do Estado de São Paulo (2012/50336-2, 2016/17951-6, 2016/50484-2)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Caveolin-1 and cellular processes
- Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
- Keywords
- calcium signaling, L-type calcium channels, neurons, glial cells, calcium homeostasis
- MeSH terms
- Alzheimer Disease, Animals, Calcium, Homeostasis, Humans, Neuroglia, Neurons, Ion Channel Gating, Calcium Signaling, Calcium Channels, L-Type
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