Clinical and research diagnostic criteria for Alzheimer's disease
Abstract
In contrast with the previous criteria published in 1984 by the National Institute of Neurological and Communicative Disorders and Stroke and the Alzheimer's Disease and Related Disorders Association, the new criteria proposed in 2007 incorporated in the diagnostic framework the use of biomarkers that are able to assess the underlying pathophysiologic mechanism. The combination of clinical and biologic approaches makes a diagnosis of Alzheimer's disease possible before the dementia stage. The core clinical criteria continue to be the cornerstone of the diagnosis in clinical practice, but biomarker evidence is expected to enhance the specificity for the diagnosis of Alzheimer's disease.
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Creation of research diagnostic criteria has proven beneficial for research in some other conditions.
“While creation of research diagnostic criteria has proven beneficial to research for some other conditions (e.g., temporomandibular joint disorders,99 Alzheimer’s Disease98 )”
From Report of the NIH Task Force on research standards for chronic low back pain. (2014) · cites this paper as [98]
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References 61 · Cited by 64
- Authors
- Sarazin, M., de Souza, L. C., Lehéricy, S., & Dubois, B.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Corresponding author
- Sarazin, Marie
- Venue
- Neuroimaging Clinics of North America
- Publisher
- Elsevier BV
- Published
- 2012-02
- Volume
- 22
- Issue
- 1
- Pages
- 23-32
- ISSN
- 1052-5149 (ISSN-L)
- OpenAlex
- W1998087244
- Cited by
- 64
- References
- 61
- Citations by year
- 2026: 4 · 2025: 2 · 2024: 2 · 2023: 3 · 2021: 4 · 2020: 4 · 2019: 2 · 2018: 2 · 2016: 5 · 2015: 5 · 2014: 14 · 2013: 10 · 2012: 6
- FWCI
- 1.52
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroimaging Clinics of North America (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cancer-related cognitive impairment studies
- Keywords
- Alzheimer's disease, diagnostic criteria, biomarkers, preclinical diagnosis, dementia, pathophysiology, diagnostic specificity
- MeSH terms
- Alzheimer Disease, Humans, United States, Clinical Medicine, Practice Guidelines as Topic, Biomedical Research, Neuroimaging
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