Neural responses to maternal praise and criticism: relationship to depression and anxiety symptoms in high-risk adolescent girls
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BACKGROUND: The parent-child relationship may be an important factor in the development of adolescent depressive and anxious symptoms. In adults, depressive symptoms relate to increased amygdala and attenuated prefrontal activation to maternal criticism. The current pilot study examined how depressive and anxiety symptoms in a high-risk adolescent population relate to neural responses to maternal feedback. Given previous research relating oxytocin to maternal behavior, we conducted exploratory analyses using oxytocin receptor (OXTR) genotype. METHODS: Eighteen females (ages 12-16) listened to maternal praise, neutral, and critical statements during functional magnetic resonance imaging. Participants completed the Mood and Feelings Questionnaire and the Screen for Child Anxiety Related Emotional Disorders. The OXTR single nucleotide polymorphism, rs53576, was genotyped. Linear mixed models were used to identify symptom or allele (GG, AA/AG) by condition (critical, neutral, praise) interaction effects on brain activation. RESULTS: Greater symptoms related to greater right amygdala activation for criticism and reduced activation to praise. For left amygdala, greater symptoms related to reduced activation to both conditions. Anxiety symptoms related to differences in superior medial PFC activation patterns. Parental OXTR AA/AG allele related to reduced activation to criticism and greater activation to praise within the right amygdala. CONCLUSIONS: Results support a relationship between anxiety and depressive symptoms and prefrontal-amygdala responses to maternal feedback. The lateralization of amygdala findings suggests separate neural targets for interventions reducing reactivity to negative feedback or increasing salience of positive feedback. Exploratory analyses suggest that parents' OXTR genetic profile influences parent-child interactions and related adolescent brain responses.
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Adolescents with or at high risk for depression show attenuated neural response to active social rewards such as maternal praise.
“as well as to active social rewards, such as maternal praise (Aupperle et al., 2016; Silk et al., 2017)”
From Neural Activation to Parental Praise Interacts With Social Context to Predict Adolescent Depressive Symptoms (2019) · cites this paper as Aupperle et al., 2016
Depression in adolescence has been linked to heightened amygdala activation to maternal criticism.
“Depression in adolescence has also been linked to heightened amygdala activation to maternal criticism (Aupperle et al., 2016)”
From Neural Activation to Parental Praise Interacts With Social Context to Predict Adolescent Depressive Symptoms (2019) · cites this paper as Aupperle et al., 2016
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References 49 · Cited by 50
- Authors
- Aupperle, R. L., Morris, A. S., Silk, J. S., Criss, M. M., Judah, M. R., Eagleton, S. G., Kirlic, N., Byrd-Craven, J., Phillips, R., & Alvarez, R. P.
- Affiliations
- Laureate Institute for Brain Research (US)
- Oklahoma State University (US)
- University of Pittsburgh (US)
- Corresponding author
- Aupperle, Robin L.
- ORCID
- Venue
- NeuroImage Clinical
- Publisher
- Elsevier BV
- Published
- 2016
- Volume
- 11
- Pages
- 548-554
- ISSN
- 2213-1582 (ISSN-L)
- PMC
- PMC4845388
- OpenAlex
- W2323989928
- Cited by
- 50
- References
- 49
- Citations by year
- 2026: 6 · 2024: 7 · 2023: 7 · 2022: 7 · 2021: 5 · 2020: 7 · 2019: 6 · 2018: 3 · 2017: 2
- FWCI
- 4.90
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- NeuroImage Clinical (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- ODU Digital Commons (Old Dominion University) (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- SHAREOK (University of Oklahoma; Oklahoma State University; Central Oklahoma University) (submittedVersion, other-oa)
- Funders
- Oklahoma Center for the Advancement of Science and Technology (HR11-130)
- William K. Warren Foundation
- Topics
- Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- maternal criticism, parent feedback, adolescent depression, adolescent anxiety, amygdala activation, medial prefrontal cortex, oxytocin receptor gene, OXTR rs53576, parent-child relationship, high-risk adolescents
- MeSH terms
- Adolescent, Amygdala, Anxiety, Brain Mapping, Child, Depression, DNA Mutational Analysis, Female, Humans, Image Processing, Computer-Assisted, Functional Laterality, Magnetic Resonance Imaging, Mother-Child Relations, Oxygen, Photic Stimulation, Psychiatric Status Rating Scales, Saliva, Social Perception, Receptors, Oxytocin, Polymorphism, Single Nucleotide, Feedback, Psychological, Self Report
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