Formation of nitric oxide from nitrous acid in ischemic tissue and skin
Abstract
Nitric oxide (NO) can form from nitrous acid under conditions of low pH and formation of the gas N2O3 is the rate-determining step. Published data allow us to calculate the rate at which NO forms from nitrite in a closed system such as circulating blood plasma. Because of the bimolecular reactions involved, and the very low concentration of nitrite, the rate of formation of NO is very slow. It might take at least 12 days, when the pH of nitrite solution is lowered, for the concentration of NO to reach a level sufficiently high to activate guanylyl cyclase and so it seems unlikely that naturally circulating nitrite is involved in vasodilation in ischemic tissue through its conversion into NO. It is more realistic to consider that NO is produced at biologically significant concentrations from nitrite in perspiration on the skin.
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Hypoxic tissue is not acidic enough to release NO from nitrite spontaneously.
“Hypoxic tissue is not acidic enough to release NO from nitrite spontaneously [88]”
From On the chemical biology of the nitrite/sulfide interaction (2015) · cites this paper as [88]
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References 27 · Cited by 45
- Authors
- Butler, A. R., & Ridd, J. H.
- Affiliations
- University of St Andrews (GB)
- University College London (GB)
- Corresponding author
- Butler, Anthony R.
- Venue
- Nitric Oxide
- Publisher
- Elsevier BV
- Published
- 2004-02
- Volume
- 10
- Issue
- 1
- Pages
- 20-24
- ISSN
- 1089-8603 (ISSN-L)
- OpenAlex
- W2050669669
- Cited by
- 45
- References
- 27
- Citations by year
- 2024: 4 · 2021: 2 · 2020: 1 · 2019: 1 · 2018: 1 · 2017: 3 · 2016: 4 · 2015: 2 · 2014: 1 · 2013: 1 · 2012: 3
- FWCI
- 1.44
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nitric Oxide (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Hemoglobin structure and function
- Keywords
- nitric oxide production, nitrous acid, nitrite, N2O3, ischemic tissue, low pH, vasodilation, reaction kinetics
- MeSH terms
- Humans, Hydrogen-Ion Concentration, Ischemia, Kinetics, Models, Chemical, Nitric Oxide, Nitrous Oxide, Skin, Sweat
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