Mitochondria as metabolizers and targets of nitrite
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Mitochondrial function is integral to maintaining cellular homeostasis through the production of ATP, the generation of reactive oxygen species (ROS) for signaling, and the regulation of the apoptotic cascade. A number of small molecules, including nitric oxide (NO), are well-characterized regulators of mitochondrial function. Nitrite, an NO metabolite, has recently been described as an endocrine reserve of NO that is reduced to bioavailable NO during hypoxia to mediate physiological responses. Accumulating data suggests that mitochondria may play a role in metabolizing nitrite and that nitrite is a regulator of mitochondrial function. Here, what is known about the interactions of nitrite with the mitochondria is reviewed, with a focus on the role of the mitochondrion as a metabolizer and target of nitrite.
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A potential mechanism by which nitrite could induce cGMP-independent effects is S-nitrosation of cysteine residues, a potential nitrite-induced post-translational modification that can alter protein function.
“A potential mechanism by which nitrite could induce cGMP-independent effects is S-nitrosation of cysteine residues, which is being increasingly recognized as a potential nitrite-induced post-translational modification that can alter protein function[17, 43, 46, 47, 51, 96].”
From Current perspectives and challenges in understanding the role of nitrite as an integral player in nitric oxide biology and therapy (2011) · cites this paper as [17]
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References 112 · Cited by 87
- Authors
- Shiva, S.
- Affiliations
- University of Pittsburgh (US)
- Corresponding author
- Shiva, Sruti
- ORCID
- Shiva, Sruti
- Venue
- Nitric Oxide
- Publisher
- Elsevier BV
- Published
- 2010-02
- Volume
- 22
- Issue
- 2
- Pages
- 64-74
- ISSN
- 1089-8603 (ISSN-L)
- PMC
- PMC2819587
- OpenAlex
- W1972205940
- Cited by
- 87
- References
- 112
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 8 · 2023: 1 · 2022: 3 · 2021: 6 · 2020: 4 · 2019: 8 · 2018: 6 · 2017: 5 · 2016: 4 · 2015: 7 · 2014: 3 · 2013: 9 · 2012: 7
- FWCI
- 0.69
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nitric Oxide (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (RC1DK085852)
- Topics
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Keywords
- nitrite, mitochondria, nitrite metabolism, mitochondrial function, reactive oxygen species, apoptosis, hypoxia, nitric oxide signaling, cellular homeostasis
- MeSH terms
- Animals, Humans, Mitochondria, Nitrites
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