Clinical translation of nitrite therapy for cardiovascular diseases
Open accessAbstract
The anion nitrite is an oxidative breakdown product of nitric oxide (NO) that has traditionally been viewed as a diagnostic marker of NO formation in biological systems. In this regard, nitrite has long been considered an inert oxidation product of NO metabolism. More recently, this view has changed with the discovery that nitrite represents a physiologically relevant storage reservoir of NO in blood and tissues that can readily be reduced to NO under pathological conditions. This has sparked a renewed interest in the biological role of nitrite and has led to an extensive amount of work investigating its therapeutic potential. As a result, nitrite therapy has now been shown to be cytoprotective in numerous animal models of disease. Given the very robust preclinical data regarding the cytoprotective effects of nitrite therapy it is very logical to consider the clinical translation of nitrite-based therapies. This article will review some of this preclinical data and will discuss the potential use of nitrite therapy as a therapeutic agent for the treatment of cardiovascular diseases including: ischemia-reperfusion injury (i.e. acute myocardial infarction and stroke), hypertension, angiogenesis, and as an adjunctive therapy for transplantation of various organs (i.e. liver and lung).
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The plethora of studies documenting protective effects of nitrite in cell culture or animal models, together with human use of nitrite in cyanide antidote kits, has laid the foundation for clinical evaluation of nitrite therapy for a variety of ischemia-related disorders.
“The plethora of studies documenting protective effects of nitrite in cell culture or animal models, together with human use of nitrite in cyanide antidote kits, has laid the foundation for clinical evaluation of nitrite therapy for a variety of ischemia related disorders (summarized in [8, 11, 117]).”
From Current perspectives and challenges in understanding the role of nitrite as an integral player in nitric oxide biology and therapy (2011) · cites this paper as [11]
Nitrite anion is recycled back to NO in multiple ways.
“However, now it is clear that nitrite anion is recycled back to NO in multiple ways.”
From Inorganic nitrite therapy: historical perspective and future directions (2011) · cites this paper as [83]
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References 89 · Cited by 72
- Authors
- Calvert, J. W., & Lefer, D. J.
- Affiliations
- Emory University (US)
- Corresponding author
- Lefer, David J.
- Venue
- Nitric Oxide
- Publisher
- Elsevier BV
- Published
- 2010-02
- Volume
- 22
- Issue
- 2
- Pages
- 91-97
- ISSN
- 1089-8603 (ISSN-L)
- PMC
- PMC3263353
- OpenAlex
- W2081413750
- Cited by
- 72
- References
- 89
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 2 · 2022: 3 · 2021: 4 · 2020: 3 · 2019: 3 · 2018: 3 · 2017: 6 · 2016: 2 · 2015: 8 · 2014: 6 · 2013: 5 · 2012: 11
- FWCI
- 0.88
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nitric Oxide (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Heart, Lung, and Blood Institute (2R01HL-060849-09, 5R01 HL-092141-01, R01HL093579, R01HL092141, R01HL060849)
- Topics
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Life Sciences › Neuroscience › Neurology › Neurological Disorders and Treatments
- Keywords
- nitrite therapy, cytoprotection, cardiovascular disease, ischemia-reperfusion injury, acute myocardial infarction, stroke, hypertension, angiogenesis, organ transplantation, liver transplantation, lung transplantation, clinical translation
- MeSH terms
- Animals, Cardiovascular Diseases, Humans, Nitrites, Translational Research, Biomedical
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