Treadmill exercise enhances passive avoidance learning in rats: The role of down-regulated serotonin system in the limbic system
Abstract
While serotonin (5-HT) may impair learning and memory, exercise has been reported to improve them. Whether chronic exercise can facilitate fear memory via regulating the serotonin system is unknown. We examined the effects of 4-week treadmill exercise training on levels of 5-HT and its metabolite 5-hydroxyindoleacetic acid (5-HIAA), the protein expression of its receptor 5-HT(1A) and transporter in the amygdala, hippocampus and prefrontal cortex of male Sprague-Dawley rats. Our results demonstrated that treadmill exercise (1) improved the passive avoidance learning performance; (2) decreased the 5-HT level in the hippocampus; (3) decreased the expression of 5-HT(1A) receptor in the amygdala without altering the transporter expression. Moreover, pretreatment with 0.1 mg/kg 8-hydroxy-di-n-propylamino tetralin, a selective 5-HT(1A) receptor agonist, impaired the passive avoidance performance and completely abolished the exercise-enhanced fear memory. Our results suggest that down-regulation of the 5-HT system in the limbic system, i.e., the reduction of the hippocampus 5-HT content and the amygdala 5-HT(1A) receptor expression, may be involved in the exercise-enhanced fear memory.
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Treadmill exercise improves hippocampus-dependent spatial learning and memory as well as aversive memory.
“Treadmill exercise also improves hippocampus-dependent spatial learning and memory as well as aversive memory [2, 3, 25, 97, 112, 174, 186, 187].”
From The neuropathology of sport (2014) · cites this paper as [25]
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References 41 · Cited by 79
- Authors
- Chen, H.-I., Lin, L.-C., Yu, L., Liu, Y.-F., Kuo, Y.-M., Huang, A.-M., Chuang, J.-I., Wu, F.-S., Liao, P.-C., & Jen, C. J.
- Affiliations
- National Cheng Kung University (TW)
- Corresponding author
- Jen, Chauying J.
- Venue
- Neurobiology of Learning and Memory
- Publisher
- Elsevier BV
- Published
- 2008-05
- Volume
- 89
- Issue
- 4
- Pages
- 489-496
- ISSN
- 1074-7427 (ISSN-L)
- OpenAlex
- W2020313112
- Cited by
- 79
- References
- 41
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 2 · 2023: 1 · 2022: 5 · 2021: 3 · 2020: 5 · 2019: 2 · 2018: 4 · 2017: 3 · 2016: 3 · 2015: 5 · 2014: 7 · 2013: 8 · 2012: 8
- FWCI
- 2.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurobiology of Learning and Memory (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Science Council
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- treadmill exercise, passive avoidance learning, fear memory, serotonin, 5-HT1A receptor, 5-hydroxyindoleacetic acid, serotonin transporter, amygdala, hippocampus, prefrontal cortex, limbic system, exercise training
- MeSH terms
- Amygdala, Animals, Avoidance Learning, Exercise Test, Fear, Hydroxyindoleacetic Acid, Limbic System, Male, Physical Conditioning, Animal, Serotonin, Down-Regulation, Rats, Sprague-Dawley, Serotonin Receptor Agonists, 8-Hydroxy-2-(di-n-propylamino)tetralin, Serotonin Plasma Membrane Transport Proteins, Rats
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