Failures to reconsolidate memory in a mouse model of Alzheimer’s disease
Open accessAbstract
Previous studies have demonstrated that the formation of spatial, contextual and trace conditioning memories are impaired in animal models of Alzheimer's disease (AD), consistent with the observations that the first sign of cognitive decline in AD includes difficulties in the acquisition of new information or memory formation. Evidence is accumulating that memory retrieval is a dynamic process in which stored information becomes labile again and needs to be restabilized. However, it is poorly understood how this process referred to as memory reconsolidation is affected in animal models of AD. The present study was designed to use contextual fear conditioning to compare the changes in memory formation and subsequent reconsolidation processes in transgenic mice that overexpress human APP and PS1 harboring five familial AD mutations (5XFAD model). The results clearly demonstrate that cognitive dysfunction starts to occur primarily as reduced levels of contextual learning or memory formation in 5XFAD mice, but it is exacerbated by additional retrieval-dependent retrograde amnesia due to deficient reconsolidation as disease further develops.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Impairment of fear conditioning in 5xFAD mice starts at 6 months of age.
“Impairment of fear conditioning in 5xFAD mice starts at 6-m of age 83 ; thus, we examined this in 6-month-old mice.”
From NAD+ hydrolase Sarm1 is a key driver of synapse degeneration and memory loss in Alzheimer’s disease (2025) · cites this paper as [83]
5XFAD mice exhibit normal reconsolidation of contextual fear memory.
“As previously reported, 5XFAD mice exhibit normal reconsolidation of contextual fear memory3161.”
From Neuronally-directed effects of RXR activation in a mouse model of Alzheimer’s disease (2017) · cites this paper as [61]
Behavioral and memory deficits do not typically begin to show significant differences in 5xFAD animals until at least 5-7 months of age.
“Interestingly, behavioral and memory deficits do not typically begin to show significant differences in 5xFAD animals until at least 5-7 months of age (Girard et al., 2014; Ohno, 2009).”
From LC3-Associated Endocytosis Facilitates β-Amyloid Clearance and Mitigates Neurodegeneration in Murine Alzheimer’s Disease (2019) · cites this paper as Ohno, 2009
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
The citation lists haven’t been fetched yet
References 40 · Cited by 95
- Authors
- Ohno, M.
- Affiliations
- New York University (US)
- Corresponding author
- Ohno, Masuo
- ORCID
- Ohno, Masuo
- Venue
- Neurobiology of Learning and Memory
- Publisher
- Elsevier BV
- Published
- 2009-10
- Volume
- 92
- Issue
- 3
- Pages
- 455-459
- ISSN
- 1074-7427 (ISSN-L)
- PMC
- PMC2772829
- OpenAlex
- W1972805775
- Cited by
- 95
- References
- 40
- Citations by year
- 2026: 1 · 2025: 10 · 2024: 7 · 2023: 5 · 2022: 5 · 2021: 3 · 2020: 6 · 2019: 5 · 2018: 4 · 2017: 3 · 2016: 5 · 2015: 12 · 2014: 8 · 2013: 10 · 2012: 4
- FWCI
- 1.77
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Neurobiology of Learning and Memory (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (R01MH067251)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Keywords
- memory reconsolidation, Alzheimer's disease, 5xFAD mice, contextual fear conditioning, memory retrieval, retrograde amnesia, APP overexpression, familial Alzheimer's disease mutations, contextual learning, cognitive impairment
- MeSH terms
- Aging, Alzheimer Disease, Animals, Conditioning, Classical, Disease Models, Animal, Fear, Humans, Learning Disabilities, Memory Disorders, Mice, Transgenic, Mutation, Receptors, Cell Surface, Amyloid beta-Protein Precursor, Mice, Presenilin-1, Protease Nexins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
