CA1 inactivation impairs episodic-like memory in rats
Open accessAbstract
Episodic memory was initially believed to be unique to humans. However, studies demonstrate that nonhuman species discriminate items based on the triad what, where and when. Here we addressed the role of the dorsal hippocampal subfield CA1 in an integrative what-where-when task in Wistar rats. We performed bilateral inactivation of dorsal CA1 with the GABA A agonist muscimol previously to the task. As expected, sham-operated animals recollected an integrative memory for objects (what), their places (where) and temporal order (when). However, the inactivation of CA1 impaired the performance of the three components of episodic-like memory. In addition, total time of objects exploration and distance traveled were not different between groups, indicating that rats had similar levels of motivation, thus, alterations in exploration does not account for impaired locomotor performance. Altogether, our data provides evidence that CA1 plays an important role in episodic-like memory.
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In the ELM2-2 test, pre-sample intra-CA1 muscimol infusions disrupted the interaction as well as the where and when components.
“pre-sample intra-CA1 muscimol infusions disrupted the interaction as well as the where and when components”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Drieskens et al., 2017
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References 36 · Cited by 31
- Authors
- Drieskens, D. C., Neves, L. R., Pugliane, K. C., de Souza, I. B. M. B., Lima, Á. D. C., Salvadori, M. G. D. S. S., Ribeiro, A. M., Silva, R. H., & Barbosa, F. F.
- Affiliations
- Universidade Federal da Paraíba (BR)
- Universidade Federal de São Paulo (BR)
- Corresponding author
- Barbosa, Flávio Freitas
- ORCID
- Venue
- Neurobiology of Learning and Memory
- Publisher
- Elsevier BV
- Published
- 2017-11
- Volume
- 145
- Pages
- 28-33
- ISSN
- 1074-7427 (ISSN-L)
- OpenAlex
- W2747857668
- Cited by
- 31
- References
- 36
- Citations by year
- 2026: 4 · 2025: 3 · 2023: 3 · 2022: 9 · 2021: 4 · 2020: 2 · 2019: 3 · 2018: 3
- FWCI
- 1.26
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neurobiology of Learning and Memory (publishedVersion)
- PubMed (publishedVersion)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, other-oa)
- Funders
- Conselho Nacional de Desenvolvimento Científico e Tecnológico (014/2013)
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- CA1, dorsal hippocampus, episodic-like memory, muscimol inactivation, object recognition memory, spatial memory, temporal order memory, rats
- MeSH terms
- Animals, Exploratory Behavior, Male, Muscimol, Rats, Wistar, CA1 Region, Hippocampal, GABA-A Receptor Agonists, Memory, Episodic
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