The effects of adolescent alcohol exposure on learning and related neurobiology in humans and rodents
Open accessAbstract
Adolescent alcohol use is a widespread problem in the United States. In both humans and rodents, alcohol can impair learning and memory processes mediated by forebrain areas such as the prefrontal cortex (PFC) and hippocampus (HC). Adolescence is a period in which alcohol use often begins, and it is also a time that can be uniquely sensitive to the detrimental effects of alcohol. Exposure to alcohol during adolescence can cause persisting alterations in PFC and HC neurobiology that are linked to cognitive impairments, including changes in neurogenesis, inflammation, and various neurotransmitter systems in rodent models. Consistent with this, chronic adolescent alcohol exposure can cause PFC-dependent learning impairments that persist into adulthood. Deficits in adult HC-dependent learning after adolescent alcohol exposure have also been reported, but these findings are less consistent. Overall, evidence summarized in this review indicates that adolescent exposure to alcohol can produce long-term detrimental effects on forebrain-dependent cognitive processes.
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Adolescent alcohol exposure has long-lasting effects on cognitive abilities.
“AAE also has long-lasting effects on cognitive abilities [53].”
From Consequences of adolescent drug use (2023) · cites this paper as [53]
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References 150 · Cited by 23
- Authors
- Seemiller, L. R., & Gould, T. J.
- Affiliations
- Pennsylvania State University (US)
- Corresponding author
- Gould, Thomas J.
- Venue
- Neurobiology of Learning and Memory
- Publisher
- Elsevier BV
- Published
- 2020-07
- Volume
- 172
- Pages
- 107234
- ISSN
- 1074-7427 (ISSN-L)
- PMC
- PMC7797082
- OpenAlex
- W3025530761
- Cited by
- 23
- References
- 150
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 5 · 2023: 7 · 2022: 4 · 2021: 2
- FWCI
- 3.12
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Neurobiology of Learning and Memory (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- adolescent alcohol exposure, learning disabilities, memory impairment, prefrontal cortex, hippocampus, neurogenesis, neuroinflammation, neurotransmitter systems, cognitive impairment, rodent models, chronic ethanol exposure
- MeSH terms
- Underage Drinking, Ethanol, Alcoholism, Animals, Hippocampus, Humans, Learning, Prefrontal Cortex, Mice, Rats, Cognitive Dysfunction
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