Polyneuropathies in teenagers: A clinicopathological study of 45 cases
Abstract
The aim of the present study was to investigate the causes of polyneuropathy in teenagers and to describe some characteristic clinical, laboratory, electrophysiological and pathological features. Forty-five patients with peripheral nervous disorders aged 13-19 were studied. Hereditary polyneuropathy of different types was diagnosed in 28 patients (62%); nine showed chronic inflammatory demyelinating polyneuropathy (CIDP) and two showed vasculitic neuropathy. In two more cases polyneuropathy was attributed to toxic agents, while among the rest, one was diagnosed as metachromatic leucodystrophy (juvenile type), one as adrenoleucodystrophy, one as porphyric neuropathy and one as Fabry disease. The high incidence of hereditary neuropathies in teenagers differs from that in adults, but is similar to that encountered in children. In our study, CIDP appears to be a frequent cause of neuropathy in teenagers, while the other causes are broadly similar to those found in studies concerning children rather than adults.
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Within 10-15 years of AMN, motor disability of the legs becomes severe, whereas arm and hand deficits remain mild.
“Within 10–15 years, motor disability of the legs becomes severe, whereas arm and hand deficits remain mild [53,54].”
From Revisiting the Pathogenesis of X-Linked Adrenoleukodystrophy (2025) · cites this paper as [53]
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Revisiting the Pathogenesis of X-Linked Adrenoleukodystrophy
Bougnères, P., & Le Stunff, C. (2025) · Genes · doi:10.3390/genes16050590 · Cited by 11 · see citing works
- Authors
- Kararizou, E., Karandreas, N., Davaki, P., Davou, R., & Vassilopoulos, D.
- Affiliations
- National and Kapodistrian University of Athens (GR)
- Corresponding author
- Kararizou, E.
- Venue
- Neuromuscular Disorders
- Publisher
- Elsevier BV
- Published
- 2006-05
- Volume
- 16
- Issue
- 5
- Pages
- 304-307
- ISSN
- 0960-8966 (ISSN-L)
- OpenAlex
- W1977991757
- Cited by
- 30
- References
- 0
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 1 · 2023: 1 · 2021: 1 · 2020: 1 · 2018: 1 · 2016: 3 · 2015: 2 · 2014: 1 · 2013: 1 · 2012: 3
- FWCI
- 2.06
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuromuscular Disorders (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Neurology › Peripheral Neuropathies and Disorders
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Hereditary Neurological Disorders
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Peripheral Nerve Disorders
- Keywords
- polyneuropathy, adolescents, hereditary neuropathy, chronic inflammatory demyelinating polyneuropathy, vasculitic neuropathy, toxic neuropathy, metachromatic leukodystrophy, adrenoleukodystrophy, Fabry disease, peripheral nerve disorders, clinicopathological features
- MeSH terms
- Adolescent, Adrenoleukodystrophy, Adult, Age Factors, Fabry Disease, Biopsy, Female, Humans, Leukodystrophy, Metachromatic, Male, Neurotoxins, Peripheral Nerves, Polyneuropathies, Porphyrias, Sural Nerve, Vasculitis, Hereditary Sensory and Motor Neuropathy, Polyradiculoneuropathy, Chronic Inflammatory Demyelinating, Microscopy, Electron, Transmission
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