Hypothesis paper brain talks with fat-evidence for a hypothalamic-pituitary-adipose axis?
Abstract
The adipose tissue signals to the brain via its secretory products. However, it is unknown whether the brain itself can directly contact the fat tissue. In order to test this hypothesis, the adipocytic expression of receptors for pituitary hormones and hypothalamic peptides was investigated. Besides FSH- and LH-receptors, adipocytes do express the specific receptors for ACTH, TSH, GH, prolactin, oxytocin and the three receptor subtypes for vasopressin. Thus, the adipose tissue might no longer be regarded as an inert and steady tissue but as a fast acting player downstream of and under the control of the brain. Based on this, the potential existence and clinical impact of a hypothalamic-pituitary-adipose axis should further be investigated.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Adipocytes and fat progenitor cells have receptors for oxytocin.
“It has been previously shown that adipocytes and fat progenitor cells have receptors for oxytocin(35, 36).”
From Oxytocin reduces caloric intake in men (2015) · cites this paper as [36]
No citation lists for this paper
No citation lists for this paper yet — checked again daily.
References 12 · Cited by 76
- Authors
- Schäffler, A., Binart, N., Schölmerich, J., & Büchler, C.
- Affiliations
- University of Regensburg (DE)
- Inserm (FR)
- Corresponding author
- Schäffler, A.
- Venue
- Neuropeptides
- Publisher
- Elsevier BV
- Published
- 2005-08
- Volume
- 39
- Issue
- 4
- Pages
- 363-367
- ISSN
- 0143-4179 (ISSN-L)
- OpenAlex
- W2028325435
- Cited by
- 76
- References
- 12
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 1 · 2023: 1 · 2022: 3 · 2021: 6 · 2020: 1 · 2019: 3 · 2018: 4 · 2017: 5 · 2016: 3 · 2015: 5 · 2014: 8 · 2013: 3 · 2012: 4
- FWCI
- 1.83
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuropeptides (publishedVersion)
- PubMed (publishedVersion)
- University of Regensburg Publication Server (University of Regensburg) (acceptedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Keywords
- adipose tissue, adipocytes, hypothalamic neuropeptides, pituitary hormones, hormone receptors, ACTH, follicle-stimulating hormone, luteinizing hormone, thyroid-stimulating hormone, growth hormone, prolactin, oxytocin, vasopressin
- MeSH terms
- Adipose Tissue, Humans, Hypothalamo-Hypophyseal System, Pituitary-Adrenal System, Receptors, Neuropeptide
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
