Oral treatment with ACCUTANE® does not increase measures of anhedonia or depression in rats

Ferguson, Sherry A.; Cisneros, F. Javier; Hanig, Joseph P.; Berry, Kimberly J.

doi:10.1016/j.ntt.2007.09.003

Oral treatment with ACCUTANE® does not increase measures of anhedonia or depression in rats

Reports of depression and/or suicide with ACCUTANE (13-cis-retinoic acid (13-cis-RA)) use prompted studies in a rodent model to ascertain its potential effects. Previously, there were no effects on measures of anhedonia (intake of a saccharin-flavored solution) and depression (forced swim test (F…