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Cited by 51Cannabis and Cannabinoid ResearchPrenatal Substance Exposure EffectsNeurotransmitter Receptor Influence on Behavior

Sexually dimorphic alterations in locomotion and reversal learning after adolescent tetrahydrocannabinol exposure in the rat

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Harte, Lauren C., Dow-Edwards, Diana·2010·Neurotoxicology and Teratology
DOI 10.1016/j.ntt.2010.05.001PMC PMC4209473
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Abstract

Research suggests that use and abuse of marijuana can be especially harmful if it occurs during adolescence, a period of vast developmental changes throughout the brain. We examined the effects of 2mg/kg (9)-tetrahydrocannabinol (THC) administered daily via intra-peritoneal injections during juvenile/early adolescence (postnatal day 22-40) or late adolescence (postnatal day 41-60) on locomotor activity, development of tolerance, and acquisition/retention of spatial avoidance in adulthood. THC caused locomotor depression in both male and female animals dosed during early adolescence but only in female animals dosed during late adolescence. Evidence of reverse tolerance to THC was seen in early adolescent animals only. In the active place avoidance test (APA), male and female animals administered THC during early adolescence made more errors on the reversal trial requiring flexibility in learning, but in animals dosed during late adolescence there were no significant sex or treatment differences. The results of the locomotor activity study indicate that females may be more sensitive to the effects of THC than males, while results of both locomotor activity and APA studies suggest that early adolescents appear to be more vulnerable to these effects than late adolescents/young adults.

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References 54 · Cited by 51

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Authors
Harte, L. C., & Dow-Edwards, D.
Affiliations
  • State University of New York (US)
  • SUNY Downstate Health Sciences University (US)
Corresponding author
Dow-Edwards, Diana
Venue
Neurotoxicology and Teratology
Publisher
Elsevier BV
Published
2010-09
Volume
32
Issue
5
Pages
515-524
ISSN
0892-0362 (ISSN-L)
DOI
10.1016/j.ntt.2010.05.001
PMC
PMC4209473
OpenAlex
W2004284072
Cited by
51
References
54
Citations by year
2026: 2 · 2025: 1 · 2024: 2 · 2023: 4 · 2022: 1 · 2021: 5 · 2020: 7 · 2019: 2 · 2018: 3 · 2017: 2 · 2016: 2 · 2015: 6 · 2013: 3 · 2012: 7
FWCI
3.11
Type
journal article
Language
en
Open access
Licence
Locations
  • Neurotoxicology and Teratology (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health
  • National Institute on Drug Abuse (R01DA019348)
Topics
  • Health Sciences › Medicine › Pharmacology › Cannabis and Cannabinoid Research
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords
tetrahydrocannabinol, adolescent drug exposure, sex differences, locomotor activity, locomotor depression, reversal learning, spatial avoidance, tolerance (pharmacology and immunology), cannabis, adolescent brain development
MeSH terms
Age Factors, Animals, Animals, Newborn, Avoidance Learning, Behavior, Animal, Female, Hallucinogens, Locomotion, Male, Retention, Psychology, Reversal Learning, Sex Characteristics, Dronabinol, Rats, Sprague-Dawley, Statistics, Nonparametric, Rats

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