The impact of caffeine on vasodilator stress perfusion studies
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Caffeine is a nonselective competitive A2A receptor antagonist and its use has been contraindicated before vasodilator MPI because it attenuates coronary hyperemia caused by adenosine and dipyridamole in a dose-dependent manner.
“The use of caffeine, a nonselective competitive A 2A receptor antagonist, has been contraindicated before vasodilator MPI (3) because it attenuates the coronary hyperemia caused by the nonselective adenosine receptor agonists adenosine and dipyridamole in a dose-dependent manner (4).”
From Interaction of Caffeine With Regadenoson-Induced Hyperemic Myocardial Blood Flow as Measured by Positron Emission Tomography (2008) · cites this paper as [4]
Previous studies found a dose-dependent attenuation of adenosine-induced and dipyridamole-induced CFR by caffeine.
“Previous studies found a dose-dependent attenuation of adenosine-induced and dipyridamole-induced CFR by caffeine (4).”
From Interaction of Caffeine With Regadenoson-Induced Hyperemic Myocardial Blood Flow as Measured by Positron Emission Tomography (2008) · cites this paper as [4]
The interaction of caffeine with adenosine-induced, dipyridamole-induced, and exercise-induced MBF changes may limit correct detection of coronary artery disease and proper management, leading to recommendation to withhold caffeine for 24 h before vasodilator stress testing.
“The interaction of caffeine with adenosine-induced, dipyridamoleinduced, and even exercise-induced MBF changes (4,6) may limit the correct detection of coronary artery disease and subsequently the proper management of the patient, leading to the general recommendation to withhold caffeine for 24 h before vasodilator stress testing (3).”
From Interaction of Caffeine With Regadenoson-Induced Hyperemic Myocardial Blood Flow as Measured by Positron Emission Tomography (2008) · cites this paper as [4]
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References 42 · Cited by 39
- Authors
- Lapeyre, A. C., Goraya, T. Y., Johnston, D. L., & Gibbons, R. J.
- Affiliations
- Mayo Clinic (US)
- ORCID
- Gibbons, Raymond J
- Venue
- Journal of Nuclear Cardiology
- Publisher
- Elsevier BV
- Published
- 2004-07
- Volume
- 11
- Issue
- 4
- Pages
- 506-511
- ISSN
- 1071-3581 (ISSN-L)
- OpenAlex
- W1976047728
- Cited by
- 39
- References
- 42
- Citations by year
- 2026: 1 · 2024: 2 · 2023: 1 · 2022: 1 · 2021: 2 · 2018: 2 · 2017: 3 · 2016: 4 · 2015: 2 · 2014: 2 · 2013: 2 · 2012: 2
- FWCI
- 0.24
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Nuclear Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Cardiac Imaging and Diagnostics
- Health Sciences › Medicine › Pharmacology › Coffee research and impacts
- Health Sciences › Medicine › Surgery › Coronary Interventions and Diagnostics
- Keywords
- caffeine, myocardial perfusion imaging, myocardial blood flow
- MeSH terms
- Caffeine, Coronary Artery Disease, Coronary Vessels, Drug Interactions, Exercise Test, Heart, Humans, Radionuclide Imaging, Sensitivity and Specificity, Vasodilator Agents, Reproducibility of Results, Artifacts
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