Discontinuation of statin therapy due to muscular side effects: A survey in real life
Abstract
Backgrounds and aims To assess the burden of statin related muscular symptom in real life.Methods and results We conducted a wide survey on 10,409 French subjects. Among these, 2850 (27%) had hypercholesterolemia and 1074 were treated with statins. Muscular symptoms were reported by 104 (10%) statin treated patients and led to discontinuation in 30% of the symptomatic patients. The main prescribed statins were low doses rosuvastatin, atorvastatin and simvastatin. Pains were the most commonly described symptoms (87%) but many patients also reported stiffness (62%), cramps (67%), weakness or a loss of strength during exertion (55%). Pain was localized in 70% but mostly described as affecting several muscular groups. Approximately 38% of patients reported that their symptoms prevented even moderate exertion during everyday activities, while 42% of patients suffered major disruption to their everyday life.Conclusion Muscular symptoms associated with average dosage statin therapy are more frequent than in clinical trials and have a greater impact on patients' life than usually thought.
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Development of SAMS interferes with the patient's quality of life and can lead to reduction of statin dose or discontinuation of statin therapy.
“Consequently, the development of SAMS interferes with the patient’s quality of life and can lead to reduction of statin dose or discontinuation of statin therapy.(10,12)”
From Effects of coenzyme Q10 supplementation on myopathy in statin-treated patients: a systematic review and meta-analysis (2025) · cites this paper as [12]
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References 22 · Cited by 111
- Authors
- Rosenbaum, D., Dallongeville, J., Sabouret, P., & Bruckert, E.
- Affiliations
- Assistance Publique – Hôpitaux de Paris (FR)
- Inserm (FR)
- Corresponding author
- Rosenbaum, D.
- ORCID
- Sabouret, P.
- Venue
- Nutrition, Metabolism and Cardiovascular Diseases
- Publisher
- Elsevier BV
- Published
- 2013-09
- Volume
- 23
- Issue
- 9
- Pages
- 871-875
- ISSN
- 0939-4753 (ISSN-L)
- OpenAlex
- W2037243117
- Cited by
- 111
- References
- 22
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 8 · 2023: 6 · 2022: 7 · 2021: 4 · 2020: 6 · 2019: 4 · 2018: 12 · 2017: 11 · 2016: 13 · 2015: 10 · 2014: 10 · 2013: 9 · 2012: 5
- FWCI
- 11.08
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nutrition Metabolism and Cardiovascular Diseases (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Merck Sharp and Dohme
- Topics
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Pharmacovigilance and Adverse Drug Reactions
- Keywords
- statin therapy, statin-induced myopathy, myalgia, statin discontinuation, hypercholesterolemia, rosuvastatin, atorvastatin, simvastatin, low-dose statins, quality of life
- MeSH terms
- Rosuvastatin Calcium, Atorvastatin, Adult, Aged, Dose-Response Relationship, Drug, Female, Fluorobenzenes, Heptanoic Acids, Humans, Hypercholesterolemia, Male, Middle Aged, Motor Activity, Muscle Cramp, Musculoskeletal Diseases, Pain, Pyrimidines, Pyrroles, Surveys and Questionnaires, Risk Factors, Sulfonamides, Treatment Outcome, Muscle, Skeletal, Muscle Weakness, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Simvastatin
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