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Vitamin D replacement ameliorates serum lipoprotein functions, adipokine profile and subclinical atherosclerosis in pre-menopausal women

Greco, D., Kocyigit, D., Adorni, M.P., Marchi, C., Ronda, N., Bernini, F., Gurses, K.M., Canpinar, H., Guc, D., Oguz, S.H., Gurlek, A., Strazzella, A., Simonelli, S., Tokgozoglu, L., Zimetti, F.·2018·Nutrition, Metabolism and Cardiovascular Diseases
DOI 10.1016/j.numecd.2018.04.010
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Abstract

Background and aims Low vitamin D (vitD) has been linked to increased cardiovascular (CV) risk, but the effects of vitD supplementation are not clarified. We evaluated the impact of vitD normalization on HDL cholesterol efflux capacity (CEC), which inversely correlates with CV risk, the proatherogenic serum cholesterol loading capacity (CLC), adipokine profile and subclinical atherosclerosis. Methods and results Healthy premenopausal women with vitD deficiency (n = 31) underwent supplementation. Subclinical atherosclerosis was evaluated by flow-mediated dilation (FMD), pulse wave velocity (PWV) and augmentation index (AIx), measured with standard techniques. HDL CEC and serum CLC were measured by a radioisotopic and fluorimetric assay, respectively. Malondialdehyde (MDA) in HDL was quantified by the TBARS assay. Pre-β HDL was assessed by 2D-electrophoresis. Serum adipokines were measured by ELISA. VitD replacement restored normal levels of serum 25-hydroxyvitamin D (25OHD) and significantly improved FMD (+4%; p 2 = 0.346; p 2 = 0.220; p = 0.009). Conclusion Our data support vitD supplementation for CV risk prevention.

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Metadata

Authors
Greco, D., Kocyigit, D., Adorni, M. P., Marchi, C., Ronda, N., Bernini, F., Gurses, K. M., Canpinar, H., Guc, D., Oguz, S. H., Gurlek, A., Strazzella, A., Simonelli, S., Tokgozoglu, L., & Zimetti, F.
ORCID
Venue
Nutrition, Metabolism and Cardiovascular Diseases
Publisher
Elsevier BV
Published
2018-08
Volume
28
Issue
8
Pages
822-829
ISSN
0939-4753
DOI
10.1016/j.numecd.2018.04.010
Cited by
18
References
0
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Funders
University of Parma

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