The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Value of triglyceride-glucose index for the estimation of ischemic stroke risk: Insights from a general population
Abstract
BACKGROUND AND AIMS Recent studies have recognized triglyceride-glucose index (TyG) as a practical surrogate of insulin resistance. Previous studies have demonstrated that insulin resistance contributes to ischemic stroke via multiple mechanisms. Our study aimed to investigate the association between TyG and prevalent ischemic stroke, exploring the value of TyG to optimize the risk stratification of ischemic stroke. METHODS AND RESULTS This cross-sectional study included 10,900 subjects (mean age: 59.95 years, 59.8% females) from rural areas of northeast China between September 2017 to May 2018. TyG was calculated as ln[fasting triglyceride (mg/dl) × fasting plasma glucose (mg/dl)/2]. The prevalence of ischemic stroke was 5.49%. After adjusting for all covariates, each SD increment of TyG caused 22.8% additional risk for ischemic stroke. When dividing TyG into quartiles, the top quartile had a 1.776 times risk for ischemic stroke against the bottom category. Furthermore, smoothing curve fitting demonstrated this association was linear in the whole range of TyG. Finally, AUC revealed an improvement when introducing TyG into clinical risk factors (0.746 vs 0.751, p = 0.029). Consistently, category-free net reclassification index (0.195, 95% CI: 0.112-0.277, P < 0.001) and integrated discrimination index (0.003, 95% CI: 0.001-0.004, P < 0.001) confirmed the improvement by TyG to stratify ischemic stroke risk. CONCLUSION The prevent ischemic stroke correlated proportionally with the increment of TyG, implicating the linearity of TyG as an indicator of ischemic stroke. Our findings suggest the potential value of TyG to optimize the risk stratification of ischemic stroke in a general population.
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Cites
Matthews, D. R., Hosker, J. P., Rudenski, A. S., Naylor, B. A., Treacher, D. F., & Turner, R. C. (1985) · Diabetologia · doi:10.1007/bf00280883 · Cited by 31,502
Effect of fatty acids on glucose production and utilization in man.
Ferrannini, E., Barrett, E. J., Bevilacqua, S., & DeFronzo, R. A. (1983) · Journal of Clinical Investigation · doi:10.1172/jci111133 · Cited by 1,050
Diabetes mellitus as a prothrombotic condition
Grant, P. J. (2007) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2007.01824.x · Cited by 443
Insulin resistance and risk for stroke
Kernan, W. N., Inzucchi, S. E., Viscoli, C. M., Brass, L. M., Bravata, D. M., & Horwitz, R. I. (2002) · Neurology · doi:10.1212/wnl.59.6.809 · Cited by 280
Cited by
Zhang, Q., Xiao, S., Jiao, X., & Shen, Y. (2023) · Cardiovascular Diabetology · doi:10.1186/s12933-023-02030-z · Cited by 477
Use of the triglyceride-glucose index (TyG) in cardiovascular disease patients
Alizargar, J., Bai, C.-H., Hsieh, N.-C., & Wu, S.-F. V. (2020) · Cardiovascular Diabetology · doi:10.1186/s12933-019-0982-2 · Cited by 403
Che, B., Zhong, C., Zhang, R., Pu, L., Zhao, T., Zhang, Y., & Han, L. (2023) · Cardiovascular Diabetology · doi:10.1186/s12933-023-01762-2 · Cited by 382
Metadata
- Authors
- Shi, W., Xing, L., Jing, L., Tian, Y., Yan, H., Sun, Q., Dai, D., Shi, L., & Liu, S.
- Venue
- Nutrition, Metabolism and Cardiovascular Diseases
- Publisher
- Elsevier BV
- Published
- 2020-02
- Volume
- 30
- Issue
- 2
- Pages
- 245-253
- ISSN
- 0939-4753 (ISSN-L)
- OpenAlex
- W2974461901
- Cited by
- 178
- References
- 4
- FWCI
- 13.25
- Type
- journal article
- Language
- en
- Open access
- closed
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- Shi, W., Xing, L., Jing, L., Tian, Y., Yan, H., Sun, Q., Dai, D., Shi, L., & Liu, S. (2020). Value of triglyceride-glucose index for the estimation of ischemic stroke risk: Insights from a general population. Nutrition, Metabolism and Cardiovascular Diseases. https://doi.org/10.1016/j.numecd.2019.09.015
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