Update on Survival in Osteosarcoma
Abstract
Osteosarcoma is the most common primary bone malignancy in children. Treatment has evolved to include systemic chemotherapy and local control surgery. Although survival improved initially in a drastic fashion with this approach, recent decades have seen little to no further gains in this area. Limb salvage surgery evolved with effective chemotherapy and advances in imaging, and continues to improve in the recent era. This article serves as a review of survival in high-grade osteosarcoma: prognostic factors, advances in chemotherapy and surgery, late effects of chemotherapy and surgery in survivors, and future directions.
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The current standard treatment for osteosarcoma is neoadjuvant chemotherapy-surgery-consolidation chemotherapy, which achieves great clinical success for patients with localized osteosarcoma.
“The current standard treatment for osteosarcoma is neoadjuvant chemotherapy-surgery-consolidation chemotherapy treatment mode, which achieves great clinical success for patients with localized osteosarcoma [5].”
From Advances on immunotherapy for osteosarcoma (2024) · cites this paper as [5]
Cites
Meyers, P. A., Schwartz, C. L., Krailo, M. D., Healey, J. H., Bernstein, M. L., Betcher, D., Ferguson, W. S., Gebhardt, M. C., Goorin, A. M., Harris, M., et al. (2008) · Journal of Clinical Oncology · doi:10.1200/jco.2008.14.0095 · Cited by 752 · see citing works
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Advances on immunotherapy for osteosarcoma
Yu, S., & Yao, X. (2024) · Molecular Cancer · doi:10.1186/s12943-024-02105-9 · Cited by 270 · see citing works
Liu, S., Wu, B., Li, X., Zhao, L., Wu, W., & Ai, S. (2021) · Journal of Oncology · doi:10.1155/2021/2719172 · Cited by 15 · see citing works
- Authors
- Anderson, M. E.
- Affiliations
- Boston Children's Hospital (US)
- Corresponding author
- Anderson, Megan E.
- ORCID
- Anderson, Megan E.
- Venue
- Orthopedic Clinics of North America
- Publisher
- Elsevier BV
- Published
- 2016-01
- Volume
- 47
- Issue
- 1
- Pages
- 283-292
- ISSN
- 0030-5898 (ISSN-L)
- OpenAlex
- W2178308549
- Cited by
- 560
- References
- 1
- Citations by year
- 2026: 17 · 2025: 32 · 2024: 49 · 2023: 68 · 2022: 69 · 2021: 69 · 2020: 90 · 2019: 63 · 2018: 44 · 2017: 44 · 2016: 15
- FWCI
- 6.08
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Orthopedic Clinics of North America (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Sarcoma Diagnosis and Treatment
- Health Sciences › Medicine › Rheumatology › Bone Tumor Diagnosis and Treatments
- Health Sciences › Medicine › Reproductive Medicine › Ovarian cancer diagnosis and treatment
- Keywords
- osteosarcoma, survival, limb salvage, systemic chemotherapy, prognostic factors, late effects of chemotherapy, high-grade osteosarcoma
- MeSH terms
- Bone Neoplasms, Humans, Neoplasm Recurrence, Local, Prognosis, Osteosarcoma, Survival Analysis, Plastic Surgery Procedures, Limb Salvage
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