The DOI matches its Crossref record.
Deletion of the Virion Host Shut-off Gene Enhances Neuronal-Selective Transgene Expression from an HSV Vector Lacking Functional IE Genes
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
R6/2 striatal MSNs exhibit altered synaptic transmission.
“As R6/2 striatal MSNs exhibit altered synaptic transmission 30,31 , we performed electrophysiological studies to evaluate whether synaptic dysfunction was reversed in R6/2-hBP2 mice.”
From SREBP2 gene therapy targeting striatal astrocytes ameliorates Huntington’s disease phenotypes (2021) · cites this paper as [30]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
No references could be resolved yet.
Research works printed but not linked: 46
- Puskovic, 2004, Prolonged biologically active transgene expression driven by HSV LAP2 in brain in vivo, Mol. Ther., 10, 67, 10.1016/j.ymthe.2004.04.004 · DOI
- Smith, 2000, Expression from the herpes simplex virus type 1 latency-associated promoter in the murine central nervous system, J. Gen. Virol., 81, 649, 10.1099/0022-1317-81-3-649 · DOI
- Zhu, 2000, Significantly increased expression of beta-glucuronidase in the central nervous system of mucopolysaccharidosis type VII mice from the latency-associated transcript promoter in a nonpathogenic herpes simplex virus type 1 vector, Mol. Ther., 2, 82, 10.1006/mthe.2000.0093 · DOI
- Palmer, 2000, Development and optimization of herpes simplex virus vectors for multiple long-term gene delivery to the peripheral nervous system, J. Virol., 74, 5604, 10.1128/JVI.74.12.5604-5618.2000 · DOI
- Perez, 2004, Comparative analysis of genomic HSV vectors for gene delivery to motor neurons following peripheral inoculation in vivo, Gene Ther., 11, 1023, 10.1038/sj.gt.3302258 · DOI
- Goss, 2011, HSV delivery of a ligand-regulated endogenous ion channel gene to sensory neurons results in pain control following channel activation, Mol. Ther., 19, 500, 10.1038/mt.2010.246 · DOI
- Goss, 2001, Antinociceptive effect of a genomic herpes simplex virus-based vector expressing human proenkephalin in rat dorsal root ganglion, Gene Ther., 8, 551, 10.1038/sj.gt.3301430 · DOI
- McMenamin, 1998, A gamma34.5 mutant of herpes simplex 1 causes severe inflammation in the brain, Neuroscience, 83, 1225, 10.1016/S0306-4522(97)00513-7 · DOI
- Scarpini, 2001, Latency associated promoter transgene expression in the central nervous system after stereotaxic delivery of replication-defective HSV-1-based vectors, Gene Ther., 8, 1057, 10.1038/sj.gt.3301497 · DOI
- Bloom, 1995, Long-term expression of a reporter gene from latent herpes simplex virus in the rat hippocampus, Brain Res. Mol. Brain Res., 31, 48, 10.1016/0169-328X(95)00031-M · DOI
- Boutell, 2013, Regulation of alphaherpesvirus infections by the ICP0 family of proteins, J. Gen. Virol., 94, 465, 10.1099/vir.0.048900-0 · DOI
- Chen, 2000, Herpes simplex virus type 1 ICP0 protein does not accumulate in the nucleus of primary neurons in culture, J. Virol., 74, 10132, 10.1128/JVI.74.21.10132-10141.2000 · DOI
- Goins, 1999, Herpes simplex virus type 1 vector-mediated expression of nerve growth factor protects dorsal root ganglion neurons from peroxide toxicity, J. Virol., 73, 519, 10.1128/JVI.73.1.519-532.1999 · DOI
- Chattopadhyay, 2005, Long-term neuroprotection achieved with latency-associated promoter-driven herpes simplex virus gene transfer to the peripheral nervous system, Mol. Ther., 12, 307, 10.1016/j.ymthe.2005.04.009 · DOI
- Margolis, 1993, Decreased reporter gene expression during latent infection with HSV LAT promoter constructs, Virology, 197, 585, 10.1006/viro.1993.1632 · DOI
- Labetoulle, 2003, HSV1 latency sites after inoculation in the lip: Assessment of their localization and connections to the eye, Invest. Ophthalmol. Vis. Sci., 44, 217, 10.1167/iovs.02-0464 · DOI
- Amelio, 2006, A chromatin insulator-like element in the herpes simplex virus type 1 latency-associated transcript region binds CCCTC-binding factor and displays enhancer-blocking and silencing activities, J. Virol., 80, 2358, 10.1128/JVI.80.5.2358-2368.2006 · DOI
- Miyagawa, 2015, Herpes simplex viral-vector design for efficient transduction of nonneuronal cells without cytotoxicity, Proc. Natl. Acad. Sci. USA, 112, E1632, 10.1073/pnas.1423556112 · DOI
- Rivas, 2016, Shutoff of host gene expression in influenza A virus and herpesviruses: Similar mechanisms and common themes, Viruses, 8, 102, 10.3390/v8040102 · DOI
- Smiley, 2004, Herpes simplex virus virion host shutoff protein: Immune evasion mediated by a viral RNase?, J. Virol., 78, 1063, 10.1128/JVI.78.3.1063-1068.2004 · DOI
- Strand, 2004, The virion host shutoff protein of herpes simplex virus type 1 has RNA degradation activity in primary neurons, J. Virol., 78, 8400, 10.1128/JVI.78.15.8400-8403.2004 · DOI
- Ferenczy, 2009, Epigenetic modulation of gene expression from quiescent herpes simplex virus genomes, J. Virol., 83, 8514, 10.1128/JVI.00785-09 · DOI
- Hobbs, 2001, Efficient activation of viral genomes by levels of herpes simplex virus ICP0 insufficient to affect cellular gene expression or cell survival, J. Virol., 75, 3391, 10.1128/JVI.75.7.3391-3403.2001 · DOI
- Glorioso, 2009, Herpes vector-mediated gene transfer in the treatment of chronic pain, Mol. Ther., 17, 13, 10.1038/mt.2008.213 · DOI
- Samaniego, 1998, Persistence and expression of the herpes simplex virus genome in the absence of immediate-early proteins, J. Virol., 72, 3307, 10.1128/JVI.72.4.3307-3320.1998 · DOI
- Dauber, 2011, The herpes simplex virus 1 vhs protein enhances translation of viral true late mRNAs and virus production in a cell type-dependent manner, J. Virol., 85, 5363, 10.1128/JVI.00115-11 · DOI
- Pasieka, 2008, Herpes simplex virus virion host shutoff attenuates establishment of the antiviral state, J. Virol., 82, 5527, 10.1128/JVI.02047-07 · DOI
- Strelow, 1995, Role of the virion host shutoff (vhs) of herpes simplex virus type 1 in latency and pathogenesis, J. Virol., 69, 6779, 10.1128/JVI.69.11.6779-6786.1995 · DOI
- Sciortino, 2013, The virion host shutoff RNase plays a key role in blocking the activation of protein kinase R in cells infected with herpes simplex virus 1, J. Virol., 87, 3271, 10.1128/JVI.03049-12 · DOI
- Suzutani, 2000, The role of the UL41 gene of herpes simplex virus type 1 in evasion of non-specific host defence mechanisms during primary infection, J. Gen. Virol., 81, 1763, 10.1099/0022-1317-81-7-1763 · DOI
- Mossman, 2000, Herpes simplex virus ICP0 mutants are hypersensitive to interferon, J. Virol., 74, 2052, 10.1128/JVI.74.4.2052-2056.2000 · DOI
- Nichol, 1994, Infection of sympathetic and sensory neurones with herpes simplex virus does not elicit a shut-off of cellular protein synthesis: Implications for viral latency and herpes vectors, Neurobiol. Dis., 1, 83, 10.1006/nbdi.1994.0011 · DOI
- Lin, 2004, The herpes simplex virus ICP0 RING finger domain inhibits IRF3- and IRF7-mediated activation of interferon-stimulated genes, J. Virol., 78, 1675, 10.1128/JVI.78.4.1675-1684.2004 · DOI
- Orzalli, 2016, Relative contributions of herpes simplex virus 1 ICP0 and vhs to loss of cellular IFI16 vary in different human cell types, J. Virol., 90, 8351, 10.1128/JVI.00939-16 · DOI
- Goins, 2011, Generation of replication-competent and -defective HSV vectors, Cold Spring Harb. Protoc., 10.1101/pdb.prot5615 · DOI
- Li, 2010, Optimal promoter usage for lentiviral vector-mediated transduction of cultured central nervous system cells, J. Neurosci. Methods, 189, 56, 10.1016/j.jneumeth.2010.03.019 · DOI
- Wilhelm, 2011, The human ubiquitin C promoter drives selective expression in principal neurons in the brain of a transgenic mouse line, Neurochem. Int., 59, 976, 10.1016/j.neuint.2011.07.008 · DOI
- Harkness, 2014, Transcription of the herpes simplex virus 1 genome during productive and quiescent infection of neuronal and nonneuronal cells, J. Virol., 88, 6847, 10.1128/JVI.00516-14 · DOI
- Knipe, 2015, Nuclear sensing of viral DNA, epigenetic regulation of herpes simplex virus infection, and innate immunity, Virology, 479-480, 153, 10.1016/j.virol.2015.02.009 · DOI
- Krisky, 1998, Deletion of multiple immediate-early genes from herpes simplex virus reduces cytotoxicity and permits long-term gene expression in neurons, Gene Ther., 5, 1593, 10.1038/sj.gt.3300766 · DOI
- Tischer, 2010, En passant mutagenesis: A two step markerless red recombination system, Methods Mol. Biol., 634, 421, 10.1007/978-1-60761-652-8_30 · DOI
- Gierasch, 2006, Construction and characterization of bacterial artificial chromosomes containing HSV-1 strains 17 and KOS, J. Virol. Methods, 135, 197, 10.1016/j.jviromet.2006.03.014 · DOI
- Uchida, 2013, Effective treatment of an orthotopic xenograft model of human glioblastoma using an EGFR-retargeted oncolytic herpes simplex virus, Mol. Ther., 21, 561, 10.1038/mt.2012.211 · DOI
- Uchida, 2010, A double mutation in glycoprotein gB compensates for ineffective gD-dependent initiation of herpes simplex virus type 1 infection, J. Virol., 84, 12200, 10.1128/JVI.01633-10 · DOI
- Berthomme, 2001, Enhancer and long-term expression functions of herpes simplex virus type 1 latency-associated promoter are both located in the same region, J. Virol., 75, 4386, 10.1128/JVI.75.9.4386-4393.2001 · DOI
- Goins, 1994, A novel latency-active promoter is contained within the herpes simplex virus type 1 UL flanking repeats, J. Virol., 68, 2239, 10.1128/JVI.68.4.2239-2252.1994 · DOI
Cited by
Sorted by citations
SREBP2 gene therapy targeting striatal astrocytes ameliorates Huntington’s disease phenotypes
Birolini, G., Verlengia, G., Talpo, F., Maniezzi, C., Zentilin, L., Giacca, M., Conforti, P., Cordiglieri, C., Caccia, C., Leoni, V., et al. (2021) · Brain · doi:10.1093/brain/awab186 · Cited by 48
Self-citation
Metadata
- Authors
- Miyagawa, Y., Verlengia, G., Reinhart, B., Han, F., Uchida, H., Zucchini, S., Goins, W. F., Simonato, M., Cohen, J. B., & Glorioso, J. C.
- Venue
- Molecular Therapy - Methods & Clinical Development
- Publisher
- Elsevier BV
- Published
- 2017-09
- Volume
- 6
- Pages
- 79-90
- ISSN
- 2329-0501
- PMC
- PMC5493822
- Cited by
- 23
- References
- 0
- Language
- en
- Funders
- NIH (NS064988, DK044935)
- CHDI Foundation (A3777, A8790)
- Commonwealth of Pennsylvania (SAP #4100061184)
- European Community (FP7-PEOPLE-2011-IAPP project 285827 [EPIXCHANGE])
- Italian Ministry for Education, University and Research (PRIN project 2010N8PBAA [INBDNF])
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review