MSD-based assays facilitate a rapid and quantitative serostatus profiling for the presence of anti-AAV antibodies

Haar, Janina; Blazevic, Dragica; Strobel, Benjamin; Kreuz, Sebastian; Michelfelder, Stefan

doi:10.1016/j.omtm.2022.04.008

MSD-based assays facilitate a rapid and quantitative serostatus profiling for the presence of anti-AAV antibodies

Adeno-associated virus (AAV) vector applications are often limited by capsid-directed humoral immune responses, mainly through neutralizing antibodies (NAbs), which are present throughout the human population due to natural AAV infections. Currently, antibody levels are often quantified via ELISA…