Intratympanic steroids for treatment of sudden hearing loss after failure of intravenous therapy
Abstract
Objective We sought to describe our experience with intratympanic steroid treatment of sudden sensorineural hearing loss after failure of intravenous steroid treatment. Study design and setting We conducted a nonrandomized prospective clinical trial. Fifty patients presenting with sudden onset idiopathic hearing loss were treated intravenously over five days. After this period, patients with treatment failure (18 cases) were offered intratympanic steroid treatment. Nine patients refused, whereas the other nine patients received three weekly injections of methylprednisolone. Recovery of hearing was reported as improvement of more than 15 dB in pure tone average. Results Intratympanic steroid treatment improved hearing loss in five patients (55%). This is significant compared with those patients who refused intratympanic treatment, who showed no further improvement (P Conclusion Intratympanic steroids significantly improve the recovery outcome of sudden hearing loss that had not recovered after intravenous steroid treatment. Significance Intratympanic steroids are an effective and safe therapy in sudden sensorineural hearing loss cases that are refractory to standard treatment.
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The population described herein likely benefited less from spontaneous recovery, which occurs within 14 days from symptom onset, and consequently had worse hearing recovery.
“The population described herein likely benefited less from spontaneous recovery, which occurs within 14 days from symptom onset, and as a consequence are associated with worse hearing recovery [14-17].”
From Intratympanic steroid administration and predictors of recovery in sudden sensorineural hearing loss (2025) · cites this paper as [17]
Spontaneous recovery occurs within 14 days from symptom onset.
“spontaneous recovery, which occurs within 14 days from symptom onset”
From Intratympanic steroid administration and predictors of recovery in sudden sensorineural hearing loss (2025) · cites this paper as [17]
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Intratympanic steroid administration and predictors of recovery in sudden sensorineural hearing loss
Kennedy, D. J., Williams, E., Wolf, L., Golden, J., Lana, A., Wiefels, M., Pyle, M., Yunis, V., & Hoffer, M. (2025) · PLOS One · doi:10.1371/journal.pone.0332809 · Cited by 4 · see citing works
- Authors
- Plaza, G., & Herráiz, C.
- Affiliations
- Hospital Universitario de Fuenlabrada (ES)
- Hospital Universitario Fundación Alcorcón (ES)
- Corresponding author
- Plaza, Guillermo
- ORCID
- Plaza, Guillermo
- Venue
- Otolaryngology–Head and Neck Surgery
- Publisher
- Wiley
- Published
- 2007-07
- Volume
- 137
- Issue
- 1
- Pages
- 74-78
- ISSN
- 0161-6439 (ISSN-L)
- 0194-5998
- 1097-6817
- OpenAlex
- W2119443867
- Cited by
- 102
- References
- 0
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 2 · 2023: 3 · 2022: 4 · 2021: 2 · 2020: 3 · 2019: 3 · 2018: 2 · 2017: 4 · 2016: 6 · 2015: 6 · 2014: 8 · 2013: 8 · 2012: 9
- FWCI
- 4.66
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Otolaryngology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Neurology › Vestibular and auditory disorders
- Life Sciences › Neuroscience › Sensory Systems › Hearing, Cochlea, Tinnitus, Genetics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Hearing Loss and Rehabilitation
- Keywords
- sudden sensorineural hearing loss, intratympanic steroid injection, methylprednisolone, intravenous corticosteroid therapy, treatment failure, hearing recovery, idiopathic hearing loss
- MeSH terms
- Anti-Inflammatory Agents, Audiometry, Pure-Tone, Auditory Threshold, Hearing Loss, Sudden, Female, Follow-Up Studies, Glucocorticoids, Hearing, Hearing Loss, Sensorineural, Humans, Injections, Injections, Intravenous, Male, Methylprednisolone, Middle Aged, Prospective Studies, Speech Discrimination Tests, Tympanic Membrane, Treatment Outcome, Treatment Failure, Recovery of Function
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