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Cited by 63Pain Management and Placebo EffectCardiovascular Health and Disease PreventionNitric Oxide and Endothelin Effects

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Modulation of pain-induced endothelial dysfunction by hypnotisability

Jambrik, Zoltan, Santarcangelo, Enrica L., Rudisch, Tibor, Varga, Albert, Forster, Tamas, Carli, Giancarlo·2005·Pain
DOI 10.1016/j.pain.2005.03.041
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Abstract

Mental stress induces endothelial dysfunction, that is a reduction of the post-occlusion brachial artery flow-mediated vasodilation (FMD). This does not occur in subjects highly susceptible to hypnosis (Highs) in either the waking or hypnotic state. The aim of the present experiment was to assess whether endothelial dysfunction is also induced by acute nociceptive stimulation and whether high hypnotisability and/or the specific instruction of analgesia prevent its occurrence in awake highly hypnotizable individuals. Thus, nine Highs and nine subjects with low susceptibility to hypnosis (Lows) underwent an experimental session including the administration of pressor pain and of pressor pain associated with the instruction of analgesia. Heart rate, basal artery diameters and brachial artery flow-mediated vasodilation were measured during stimulation and rest conditions. Heart rate exhibited slight changes not modulated by hypnotisability. During painful stimulation both Highs and Lows showed a decrease of FMD, but it was significantly less pronounced in Highs. During the administration of painful stimulation together with the instruction of analgesia, only Highs reported analgesia and their FMD no longer decreased. This study provides the first evidence of pain-related endothelial dysfunction and extends previous findings concerning a sort of natural protection of Highs against the vascular effects of mental stress to acute pain.

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  • Recent evidence suggests a role for nitric oxide (NO) because hypnotizability-related vascular responses to cognitive and physical stimulation indicate greater NO availability in the highs' vessels.

    “Recent evidence suggests a role for nitric oxide (NO) because the hypnotizability-related vascular responses to cognitive and physical stimulation indicate greater NO availability in the highs’ vessels (Jambrik et al., 2004; Jambrik et al., 2005).”

    From Hypnotizability and Catechol-O-Methyltransferase (COMT) polymorphysms in Italians (2014) · cites this paper as Jambrik et al., 2005

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Metadata

Authors
Jambrik, Z., Santarcangelo, E. L., Rudisch, T., Varga, A., Forster, T., & Carli, G.
Affiliations
  • University of Pisa (IT)
  • University of Szeged (HU)
  • University of Siena (IT)
Corresponding author
Carli, Giancarlo
ORCID
Venue
Pain
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2005-08
Volume
116
Issue
3
Pages
181-186
ISSN
0304-3959 (ISSN-L)
DOI
10.1016/j.pain.2005.03.041
OpenAlex
W2035356574
Cited by
63
References
0
Citations by year
2025: 2 · 2023: 2 · 2022: 5 · 2021: 4 · 2020: 5 · 2019: 1 · 2018: 3 · 2017: 1 · 2016: 4 · 2015: 4 · 2014: 4 · 2013: 2 · 2012: 1
FWCI
2.03
Type
journal article
Language
en
Open access
closed
Locations
  • Pain (publishedVersion)
  • PubMed (publishedVersion)
  • CINECA IRIS Institutial research information system (University of Pisa) (submittedVersion)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Pain Management and Placebo Effect
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
  • Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Keywords
hypnotic analgesia, endothelial dysfunction, flow-mediated dilation, acute pain, psychological stress, brachial artery, heart rate
MeSH terms
Adult, Analysis of Variance, Endothelium, Vascular, Female, Heart Rate, Humans, Hypnosis, Hypnosis, Anesthetic, Functional Laterality, Pain, Pain Measurement, Pressure, Regional Blood Flow, Time Factors, Vascular Diseases, Vasodilation

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