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Cited by 443Pain Management and Placebo EffectPain Mechanisms and TreatmentsMemory and Neural Mechanisms

The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.

How prior experience shapes placebo analgesia

Colloca, Luana, Benedetti, Fabrizio·2006·Pain
DOI 10.1016/j.pain.2006.04.005
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Abstract

Some studies indicate that placebo analgesia is stronger when pre-conditioning with effective analgesic treatments is performed, thereby suggesting that the placebo response is a learning phenomenon. Here we further tested this hypothesis in order to better understand when and how previous experience affects the placebo analgesic response. To do this, we used a conditioning procedure whereby the intensity of painful stimulation was reduced surreptitiously, so as to make the subjects believe that an analgesic treatment was effective. This procedure induced strong placebo responses after minutes, and these responses, albeit reduced, lasted up to 4-7 days. In addition, in a second group of subjects we repeated the same conditioning procedure 4-7 days after a totally ineffective analgesic treatment, and found that the placebo responses were remarkably reduced compared to the first group. Thus we obtained small, medium and large placebo responses, depending on several factors, such as the previous positive or negative experience of an analgesic treatment and the time lag between the treatment and the placebo responses. We also ran extinction trials, and found that these effects did not undergo extinction in a time span of several minutes. These findings indicate that placebo analgesia is finely tuned by prior experience and these effects may last, albeit reduced, several days. These results emphasize that the placebo effect is a learning phenomenon in which many factors come into…

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Metadata

Authors
Colloca, L., & Benedetti, F.
Affiliations
University of Turin (IT)
ORCID
Venue
Pain
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2006-09
Volume
124
Issue
1
Pages
126-133
ISSN
0304-3959 (ISSN-L)
DOI
10.1016/j.pain.2006.04.005
OpenAlex
W2042891620
Cited by
443
References
34
Citations by year
2026: 18 · 2025: 28 · 2024: 24 · 2023: 24 · 2022: 16 · 2021: 15 · 2020: 31 · 2019: 28 · 2018: 31 · 2017: 27 · 2016: 25 · 2015: 28 · 2014: 35 · 2013: 23 · 2012: 15
FWCI
6.47
Type
journal article
Language
en
Open access
closed
Locations
  • Pain (publishedVersion)
  • PubMed (publishedVersion)
  • Institutional Research Information System University of Turin (University of Turin) (submittedVersion)
Funders
Ministero dell'Università e della Ricerca
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Pain Management and Placebo Effect
  • Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords
placebo analgesia, placebo response, prior experience, conditioning, learning, extinction, analgesic treatment, pain perception
MeSH terms
Adult, Analgesia, Analysis of Variance, Child, Electroshock, Female, Humans, Male, Pain, Pain Measurement, Placebos, Placebo Effect, Pain Threshold

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