Cited by 219Pain Management and Placebo EffectPain Mechanisms and TreatmentsNeural and Behavioral Psychology Studies

The DOI matches its Crossref record; 66 of the 66 references it cites were found in a registry or an index.

Modulation of pain ratings by expectation and uncertainty: Behavioral characteristics and anticipatory neural correlates

Open access

Brown, Christopher A., Seymour, Ben, Boyle, Yvonne, El-Deredy, Wael, Jones, Anthony K.P.·2008·Pain

DOI 10.1016/j.pain.2007.05.022

Open this paper in CoChat — free account

Abstract

Expectations about the magnitude of impending pain exert a substantial effect on subsequent perception. However, the neural mechanisms that underlie the predictive processes that modulate pain are poorly understood. In a combined behavioral and high-density electrophysiological study we measured anticipatory neural responses to heat stimuli to determine how predictions of pain intensity, and certainty about those predictions, modulate brain activity and subjective pain ratings. Prior to receiving randomized laser heat stimuli at different intensities (low, medium or high) subjects (n=15) viewed cues that either accurately informed them of forthcoming intensity (certain expectation) or not (uncertain expectation). Pain ratings were biased towards prior expectations of either high or low intensity. Anticipatory neural responses increased with expectations of painful vs. non-painful heat intensity, suggesting the presence of neural responses that represent predicted heat stimulus intensity. These anticipatory responses also correlated with the amplitude of the Laser-Evoked Potential (LEP) response to painful stimuli when the intensity was predictable. Source analysis (LORETA) revealed that uncertainty about expected heat intensity involves an anticipatory cortical network commonly associated with attention (left dorsolateral prefrontal, posterior cingulate and bilateral inferior parietal cortices). Relative certainty, however, involves cortical areas previously associated with semantic and prospective memory (left inferior frontal and inferior temporal cortex, and right anterior prefrontal cortex). This suggests that biasing of pain reports and LEPs by expectation involves temporally precise activity in specific cortical networks.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.pain.2007.05.022

Cites

66 of 66 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Control of goal-directed and stimulus-driven attention in the brain
Corbetta, M., & Shulman, G. L. (2002) · Nature Reviews Neuroscience · doi:10.1038/nrn755 · Cited by 12,881
The attention system of the human brain
Posner, M. I., & Petersen, S. E. (1990) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.13.030190.000325 · Cited by 8,070
Mindfulness: A proposed operational definition.
Bishop, S. R., Lau, M., Shapiro, S., Carlson, L., Anderson, N. D., Carmody, J., Segal, Z. V., Abbey, S., Speca, M., Velting, D., et al. (2004) · Clinical Psychology: Science and Practice · doi:10.1093/clipsy.bph077 · Cited by 7,234
Nonparametric permutation tests for functional neuroimaging: A primer with examples
Nichols, T. E., & Holmes, A. P. (2002) · Human Brain Mapping · doi:10.1002/hbm.1058 · Cited by 6,256
Predictive coding in the visual cortex: a functional interpretation of some extra-classical receptive-field effects
Rao, R. P. N., & Ballard, D. H. (1999) · Nature Neuroscience · doi:10.1038/4580 · Cited by 5,483
Fear-avoidance and its consequences in chronic musculoskeletal pain: a state of the art.
Vlaeyen, J. W. S., & Linton, S. J. (2000) · Pain · doi:10.1016/s0304-3959(99)00242-0 · Cited by 4,931
A theory of cortical responses.
Friston, K. (2005) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2005.1622 · Cited by 4,578
A Solution for Reliable and Valid Reduction of Ocular Artifacts, Applied to the P300 ERP
Semlitsch, H. V., Anderer, P., Schuster, P., & Presslich, O. (1986) · Psychophysiology · doi:10.1111/j.1469-8986.1986.tb00696.x · Cited by 2,024
Placebo-Induced Changes in fMRI in the Anticipation and Experience of Pain
Wager, T. D., Rilling, J. K., Smith, E. E., Sokolik, A., Casey, K. L., Davidson, R. J., Kosslyn, S. M., Rose, R. M., & Cohen, J. D. (2004) · Science · doi:10.1126/science.1093065 · Cited by 1,992
The Architecture of Cognitive Control in the Human Prefrontal Cortex
Koechlin, É., Ody, C., & Kouneiher, F. (2003) · Science · doi:10.1126/science.1088545 · Cited by 1,939

Show all 66 references

Sorted by citations

Items 101–200 of 219

Anchors as Semantic Primes in Value Construction: An EEG Study of the Anchoring Effect
Ma, Q., Li, D., Shen, Q., & Qiu, W. (2015) · PLoS ONE · doi:10.1371/journal.pone.0139954 · Cited by 16
The Influence of Pain-Related Expectations on Intensity Perception of Nonpainful Somatosensory Stimuli
Zaman, J., Wiech, K., Claes, N., Oudenhove, L. V., Diest, I. V., & Vlaeyen, J. W. S. (2018) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000586 · Cited by 18
The brain in pain.
Ahmad, A. H., & Aziz, C. B. A. (2014) · Europe PMC (PubMed Central) · Cited by 16
Effects of Language on Visual PerceptionPreprint
Lupyan, G., Rahman, R. A., Boroditsky, L., & Clark, A. (2020) · PsyArXiv (OSF Preprints) · doi:10.31234/osf.io/pztmc · Cited by 23
A novel computational approach to pain perception modelling within a Bayesian framework using quantitative sensory testing
Drusko, A., Baumeister, D., McPhee, M. E., Kold, S., Fisher, V., Treede, R., Powers, A. R., Graven‐Nielsen, T., & Tesarz, J. (2023) · Scientific Reports · doi:10.1038/s41598-023-29758-8 · Cited by 16
Impaired pain-related threat and safety learning in patients with chronic back pain
Schlitt, F., Schmidt, K., Merz, C. J., Wolf, O. T., Kleine‐Borgmann, J., Elsenbruch, S., Wiech, K., Forkmann, K., & Bingel, U. (2021) · Pain · doi:10.1097/j.pain.0000000000002544 · Cited by 14
Do nociceptive stimulation intensity and temporal predictability influence pain-induced corticospinal excitability modulation?
Neige, C., Brun, C., Gagné, M., Bouyer, L. J., & Mercier, C. (2020) · NeuroImage · doi:10.1016/j.neuroimage.2020.116883 · Cited by 13
The Placebo Effect in Psychosis: Why It Matters and How to Measure It
Hird, E., Diederen, K. M. J., Leucht, S., Jensen, K. B., & McGuire, P. K. (2023) · Biological Psychiatry Global Open Science · doi:10.1016/j.bpsgos.2023.02.008 · Cited by 14
The effect of unpredictability on the perception of pain: a systematic review and meta-analysis
Pavy, F., Zaman, J., Noortgate, W. V. D., Scarpa, A., von Leupoldt, A., & Torta, D. M. E. (2024) · Pain · doi:10.1097/j.pain.0000000000003199 · Cited by 17
Attention Modulates Neural Responses to Unpredictable Emotional Faces in Dorsolateral Prefrontal Cortex
Ran, G., Chen, X., Zhang, Q., Ma, Y., & Zhang, X. (2016) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2016.00332 · Cited by 14
The influence of social signals on the self-experience of pain: A neuroimaging review
Sharvit, G., & Schweinhardt, P. (2022) · Frontiers in Neurology · doi:10.3389/fneur.2022.856874 · Cited by 11
Alpha transcranial alternating current stimulation modulates pain anticipation and perception in a context-dependent manner
Li, X., Jin, R., Lu, X., Zhan, Y., Jiang, N., & Peng, W. (2024) · Pain · doi:10.1097/j.pain.0000000000003452 · Cited by 13
The role of pain expectancy and its confidence in placebo hypoalgesia and nocebo hyperalgesia
Camerone, E. M., Tosi, G., & Romano, D. (2024) · Pain · doi:10.1097/j.pain.0000000000003495 · Cited by 15
Prolonged Pain Research in Mice: Trends in Reference to the 3Rs
Balcombe, J. P., Ferdowsian, H. R., & Briese, L. (2013) · Journal of Applied Animal Welfare Science · doi:10.1080/10888705.2013.741004 · Cited by 13
Impact of physical therapists’ instructions on function and the perception of post-dry needling soreness in mechanical cervical pain; a randomized clinical trial
Nejad, F. A., Dommerholt, J., Moghadam, B. A., Shadmehr, A., & Pour, Z. K. (2020) · Journal of Bodywork and Movement Therapies · doi:10.1016/j.jbmt.2020.06.023 · Cited by 13
Certainty in ascending sensory signals – The unexplored driver of analgesic placebo response
Kuperman, P., Talmi, D., Katz, N., & Treister, R. (2020) · Medical Hypotheses · doi:10.1016/j.mehy.2020.110113 · Cited by 13
Not my body, not my pain? Pain perception and placebo analgesia in individuals with body integrity dysphoria
Ho, J. T., Krummenacher, P., & Lenggenhager, B. (2022) · Cortex · doi:10.1016/j.cortex.2022.03.023 · Cited by 12
The application of transcutaneous electrical nerve stimulation to acupuncture points (Acu-TENS) for pain relief: a discussion of efficacy and potential mechanisms
Brown, L., Holmes, M., & JONES, A. Y. M. (2009) · Physical Therapy Reviews · doi:10.1179/174328809x405964 · Cited by 13
Self-citation
Laser evoked potentials in fibromyalgia with peripheral small fiber involvement
Vecchio, E., Quitadamo, S. G., Ricci, K., Libro, G., Delussi, M. D., Lombardi, R., Lauria, G., & de Tommaso, M. (2022) · Clinical Neurophysiology · doi:10.1016/j.clinph.2022.01.001 · Cited by 14
Transcranial random noise stimulation over the left dorsolateral prefrontal cortex attenuates pain expectation and perception
Li, X., Yao, J., Lin, X., Chen, S., Jin, R., & Peng, W. (2022) · Clinical Neurophysiology · doi:10.1016/j.clinph.2022.12.009 · Cited by 13
Pain anticipatory phenomena in patients with central poststroke pain: a magnetoencephalography study
Gopalakrishnan, R., Burgess, R. C., Lempka, S. F., Gale, J. T., Floden, D. P., & Machado, A. G. (2016) · Journal of Neurophysiology · doi:10.1152/jn.00215.2016 · Cited by 12
Noxious pressure stimulation demonstrates robust, reliable estimates of brain activity and self-reported pain
Jackson, J. B., O’Daly, O., Makovac, E., Medina, S., Rubio, A. D. L., McMahon, S. B., Williams, S., & Howard, M. A. (2020) · NeuroImage · doi:10.1016/j.neuroimage.2020.117178 · Cited by 12
Inter-individual differences in pain anticipation and pain perception in migraine: Neural correlates of migraine frequency and cortisol-to-dehydroepiandrosterone sulfate (DHEA-S) ratio
Kökönyei, G., Galambos, A., Kocsel, N., Szabó, E., Édes, A. E., Gecse, K., Baksa, D., Pap, D., Kozák, L. R., Bagdy, G., et al. (2021) · PLoS ONE · doi:10.1371/journal.pone.0261570 · Cited by 12
A neurophysiological investigation of anticipation to pain in Parkinson's disease
Martin, S. L., Jones, A. K. P., Brown, C. A., Kobylecki, C., & Silverdale, M. (2019) · European Journal of Neuroscience · doi:10.1111/ejn.14559 · Cited by 11
Self-citation
Size Reduction of the Right Amygdala in Chronic Pain Patients with Emotional Stress: A Systematic Review and Meta-Analysis
Chen, M., Sun, C., Lin, I., Suen, M., Sue, Y., Chen, I.-L., Lin, C., & Yeh, P. (2022) · Pain Medicine · doi:10.1093/pm/pnac162 · Cited by 10
Pain perception as hierarchical Bayesian inference: A test case for the theory of constructed emotion
Poublan‐Couzardot, A., & Talmi, D. (2024) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.15141 · Cited by 14
Graph Metrics Reveal Brain Network Topological Property in Neuropathic Pain Patients: A Systematic Review
Xin, H., Yang, B., Jia, Y., Qi, Q., Wang, Y., Wang, L., Chen, X., Li, F., Lu, J., & Chen, N. (2024) · Journal of Pain Research · doi:10.2147/jpr.s483466 · Cited by 10
Inferences of Others' Competence Reduces Anticipation of Pain When under Threat
Tedeschi, E., Weber, J., Prévost, C., Mischel, W., & Mobbs, D. (2015) · Journal of Cognitive Neuroscience · doi:10.1162/jocn_a_00843 · Cited by 11
Dissociating the neural mechanisms of pain consistency and pain intensity in the trigemino-nociceptive system
Kröger, I. L., Menz, M. M., & May, A. (2015) · Cephalalgia · doi:10.1177/0333102415612765 · Cited by 10
The effects of unpredictability and negative affect on perception and neural gating in different interoceptive modalities
Jelinčić, V., Torta, D. M. E., Diest, I. V., & von Leupoldt, A. (2022) · Biological Psychology · doi:10.1016/j.biopsycho.2022.108267 · Cited by 10
Adult-Age Inflammatory Pain Experience Enhances Long-Term Pain Vigilance in Rats
Li, S.-G., Wang, J., & Luo, F. (2012) · PLoS ONE · doi:10.1371/journal.pone.0036767 · Cited by 10
Negative expectations interfere with the analgesic effect of safety cues on pain perception by priming the cortical representation of pain in the midcingulate cortex
Almarzouki, A. F., Brown, C. A., Brown, R. J., Leung, M., & Jones, A. K. P. (2017) · PLoS ONE · doi:10.1371/journal.pone.0180006 · Cited by 12
Self-citation
Unveiling the Role of Contingent Negative Variation (CNV) in Migraine: A Review of Electrophysiological Studies in Adults and Children
Lahoz, M. E. D., Barjola, P., Peláez, I., Ferrera, D., Fernandes-Magalhaes, R., & Mercado, F. (2023) · Biomedicines · doi:10.3390/biomedicines11113030 · Cited by 9
Neural representations of aversive value encoding in pain catastrophizers
Brown, C. A., Almarzouki, A. F., Brown, R. J., & Jones, A. K. P. (2018) · NeuroImage · doi:10.1016/j.neuroimage.2018.09.052 · Cited by 9
Self-citation
Testosterone administration enhances the expectation and perception of painful and non-painful somatosensory stimuli
Zhuo, S., Zhang, Y., Lin, C., & Peng, W. (2023) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2023.106081 · Cited by 9
Effect of expectation on pain assessment of lower- and higher-intensity stimuli
Ružić, V., Ivanec, D., & Stanke, K. M. (2016) · Scandinavian Journal of Pain · doi:10.1016/j.sjpain.2016.09.013 · Cited by 10
Uncertain is worse
Ma, Q., Qiu, W., Fu, H., & Sun, X. (2018) · Neuroreport · doi:10.1097/wnr.0000000000001061 · Cited by 9
Others' Pain Appraisals Modulate the Anticipation and Experience of Subsequent Pain
Peng, W., Peng, H., Lu, J., Fan, B., & Cui, F. (2019) · Neuroscience · doi:10.1016/j.neuroscience.2019.04.055 · Cited by 11
Modulation of the sensory and affective dimensions of pain by expectations and uncertainty: a Bayesian modeling approachPreprint
Poublan‐Couzardot, A., Pagnoni, G., & Antoine Lutz, A. (2022) · OSF Preprints (OSF Preprints) · doi:10.31219/osf.io/nteg7 · Cited by 8
Hacking the Predictive Mind
Clark, A. (2024) · Entropy · doi:10.3390/e26080677 · Cited by 10
Early event related fields during visually evoked pain anticipation
Gopalakrishnan, R., Burgess, R. C., Plow, E. B., Floden, D. P., & Machado, A. G. (2015) · Clinical Neurophysiology · doi:10.1016/j.clinph.2015.11.019 · Cited by 9
Prediction and unconscious attention operate synergistically to facilitate stimulus processing: An fMRI study
Ran, G., Chen, X., Cao, X., & Zhang, Q. (2016) · Consciousness and Cognition · doi:10.1016/j.concog.2016.06.016 · Cited by 7
Stimulus predictability moderates the withdrawal strategy in response to repetitive noxious stimulation in humans
Jure, F. A., Arguissain, F. G., Manresa, J. A. B., Graven‐Nielsen, T., & Andersen, O. K. (2020) · Journal of Neurophysiology · doi:10.1152/jn.00028.2020 · Cited by 7
When experience is not enough: learning-based cognitive pain modulation with or without instructions
Zaman, J., Vlaeyen, J. W. S., & Wiech, K. (2021) · Pain · doi:10.1097/j.pain.0000000000002322 · Cited by 8
Electrophysiological indices of pain expectation abnormalities in fibromyalgia patients
Barjola, P., Peláez, I., Ferrera, D., González, J. L., Furlong, L. V., Peñacoba, C., López‐López, A., Fernandes-Magalhaes, R., & Mercado, F. (2022) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2022.943976 · Cited by 7
Red induces hyperalgesia and white induces hypoalgesia regardless of pain modality
Wiercioch‐Kuzianik, K., Brączyk, J., Bieniek, H., & Bąbel, P. (2023) · Scientific Reports · doi:10.1038/s41598-023-33313-w · Cited by 6
Effects of oral alcohol administration on heat pain threshold and ratings of supra-threshold stimuli
Capito, E. S., Lautenbacher, S., Wolstein, J. R., & Horn‐Hofmann, C. (2020) · Scandinavian Journal of Pain · doi:10.1515/sjpain-2019-0144 · Cited by 7
The effect of unpredictability on the perception of breathlessness: a narrative review
Pavy, F., Torta, D. M. E., & von Leupoldt, A. (2024) · Frontiers in Rehabilitation Sciences · doi:10.3389/fresc.2023.1339072 · Cited by 5
Modulatory Effects of Prediction Accuracy on Electroencephalographic Brain Activity During Prediction
Ono, K., Hashimoto, J., Hiramoto, R., Sasaoka, T., & Yamawaki, S. (2021) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2021.630288 · Cited by 5
Evidence for Cognitive Placebo and Nocebo Effects in Healthy IndividualsPreprint
Turi, Z., Bjørkedal, E., Gunkel, L., Antal, A., Paulus, W., & Mittner, M. (2018) · doi:10.31234/osf.io/87kea · Cited by 5
Multivariate prediction of pain perception based on pre-stimulus activity
Taesler, P., & Rose, M. (2022) · Scientific Reports · doi:10.1038/s41598-022-07208-1 · Cited by 4
The Impact of Alpha‐Neurofeedback Training on Gastric Slow Wave Activity and Heart Rate Variability in Humans
Mathew, J., Galacgac, J., Smith, M. L., Du, P., & Çakmak, Y. Ö. (2025) · Neurogastroenterology & Motility · doi:10.1111/nmo.15009 · Cited by 4
How does EEG Contribute to Our Understanding of the Placebo Response?
Jones, A. K. P., Brown, C. A., & El‐Deredy, W. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-397928-5.00005-2 · Cited by 4
Self-citation
Anticipatory Brain Responses and Expectancy Effects on Pain: Theory, Research Findings and Functional Networks
Brown, C. A. (2017) · Springer eBooks · doi:10.1007/978-3-319-48046-6_6 · Cited by 5
Self-citation
Repeated exposure to aversive sensations differentially affects neural gating and bodily perception
Jelinčić, V., Torta, D. M. E., Bossche, L. V., Diest, I. V., & von Leupoldt, A. (2023) · Behaviour Research and Therapy · doi:10.1016/j.brat.2023.104422 · Cited by 4
Updating beliefs about pain following advice: Trustworthiness of social advice predicts pain expectations and experience
Krahé, C., Koukoutsakis, A., & Fotopoulou, A. (2024) · Cognition · doi:10.1016/j.cognition.2024.105756 · Cited by 4
Periprocedural Pain of Radiofrequency Ablation for Hepatocellular Carcinoma
Hori, M., Tanaka, M., Suzuki, Y., Fukao, M., Shimizu, H., Mikoshiba, N., & Tateishi, R. (2011) · Gastroenterology Nursing · doi:10.1097/sga.0b013e318210c084 · Cited by 4
Expectation generation and its effect on subsequent pain and visual perception
Botvinik‐Nezer, R., Geuter, S., Lindquist, M. A., & Wager, T. D. (2025) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1013053 · Cited by 3
Expecting pain
de Vignemont, F. (2023) · Synthese · doi:10.1007/s11229-023-04394-x · Cited by 3
Exploring the neural underpinnings of chord prediction uncertainty: an electroencephalography (EEG) study
Ono, K., Mizuochi, R., Yamamoto, K., Sasaoka, T., & Ymawaki, S. (2024) · Scientific Reports · doi:10.1038/s41598-024-55366-1 · Cited by 2
Was it “conditioned” or “suggested” pain? Reply to S. Kang et al.
Esposto, M., & Cioeta, M. (2024) · Pain · doi:10.1097/j.pain.0000000000003191 · Cited by 3
Brain Imaging of Pain
Caulo, M., Maruotti, V., & Ferretti, A. (2019) · Springer eBooks · doi:10.1007/978-3-319-99822-0_2 · Cited by 3
Role of Central Neurophysiological Systems In Placebo Analgesia and Their Relationships With Cognitive Processes Mediating Placebo Responding
Brown, C. A., Watson, A., Morton, D. L., Power, A., El‐Deredy, W., & Jones, A. K. P. (2011) · Future Neurology · doi:10.2217/fnl.11.21 · Cited by 3
Self-citation
Pain Uncertainty in Patients with Fibromyalgia, Yoga Practitioners, and Healthy Volunteers
Bradshaw, D. H., Donaldson, G. W., & Okifuji, A. (2012) · International Journal of Yoga Therapy · doi:10.17761/ijyt.22.1.q88210r783u4556p · Cited by 4
Commentary on: Practical Guidance for Optimizing Patient Comfort During Microfocused Ultrasound With Visualization and Improving Patient Satisfaction
Duncan, D. I. (2019) · Aesthetic Surgery Journal · doi:10.1093/asj/sjz123 · Cited by 3
Expectations and uncertainty shape pain perception during learning
Lacombe-Thibault, M., & Coll, M. (2025) · Journal of Pain · doi:10.1016/j.jpain.2025.105569 · Cited by 2
Reward prediction error in the ERP following unconditioned aversive stimuli
Stewardson, H. J., & Sambrook, T. D. (2021) · Scientific Reports · doi:10.1038/s41598-021-99408-4 · Cited by 2
Altered Pain Processing Associated with Administration of Dopamine Agonist and Antagonist in Healthy Volunteers
Martin, S. L., Jones, A. K. P., Brown, C. A., Kobylecki, C., Whitaker, G. A., El‐Deredy, W., & Silverdale, M. (2022) · Brain Sciences · doi:10.3390/brainsci12030351 · Cited by 2
Self-citation
Incongruent virtual reality attenuates breathlessness and leg fatigue during stationary cycling
Biller, L., Starling, L., Sinha, A., Dearlove, D., Bruce, R. M., Runswick, O. R., Taylor, S., Sergeant, M., Finnegan, S., & Pattinson, K. T. S. (2026) · Virtual Reality · doi:10.1007/s10055-026-01391-6 · Cited by 2
Isolating Brain Mechanisms of Expectancy Effects on Pain: Cue-Based Stimulus Expectancies versus Placebo-Based Treatment Expectancies
Necka, E. A., Akintola, T., Yu, Q., Amir, C., Oretsky, O., & Atlas, L. Y. (2025) · Journal of Neuroscience · doi:10.1523/jneurosci.0050-25.2025 · Cited by 5
The Oncological Patient in the Palliative Situation
Eychmueller, S., Zwahlen, D., & Fliedner, M. (2013) · Recent results in cancer research/Recent Results in Cancer Research · doi:10.1007/978-3-642-40187-9_5 · Cited by 2
Jumping to conclusions in persistent pain using a somatosensory modification of the beads task
Parkes, C., Bezzina, O., Chapman, A., Luteran, A., Freeston, M. H., & Robinson, L. J. (2019) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2019.109819 · Cited by 2
The Oncological Patient in the Palliative Situation
Eychmueller, S., Zwahlen, D., & Fliedner, M. (2017) · Recent results in cancer research/Recent Results in Cancer Research · doi:10.1007/978-3-319-64310-6_5 · Cited by 2
EVALUATION OF ANALGESIC ACTIVITY OF ROOTS OF PICRORHIZA KURROA
Shid, R. L., Raha, S. B., & Shid, S. L. (2013) · Journal of Drug Delivery and Therapeutics · doi:10.22270/jddt.v3i4.557 · Cited by 2
Expectations underlie the effects of unpredictable pain: a behavioral and EEG studyPreprint
Pavy, F., Zaman, J., von Leupoldt, A., & Torta, D. M. E. (2023) · doi:10.31234/osf.io/rwa57 · Cited by 2
The effect of unpredictability on the perception of pain: A systematic review and meta-analysisPreprint
Pavy, F., Zaman, J., Noortgate, W. V. D., Scarpa, A., von Leupoldt, A., & Torta, D. M. E. (2023) · doi:10.31234/osf.io/4wez7 · Cited by 2
Validating a measure of the precision of ascending noxious signalsPreprint
Singh, A., Treister, R., Charalambous, C., Mancini, F., & Talmi, D. (2024) · doi:10.31234/osf.io/9s5gj · Cited by 2
Pain without inference
Casser, L. (2024) · Philosophy and Phenomenological Research · doi:10.1111/phpr.13134 · Cited by 1
Contingency awareness shapes neural responses in fear conditioning
Pavlov, Y. G., Menger, N. S., Keil, A., & Kotchoubey, B. (2025) · Neuroscience of Consciousness · doi:10.1093/nc/niaf065 · Cited by 1
Placebo and nocebo effects on pain through the lens of the predictive brain: Neurobiological mechanisms and translational implications
Zamfira, D. A., Fassina, T., Zaworski, K., Carlino, E., & Rossettini, G. (2026) · Experimental Physiology · doi:10.1113/ep093418 · Cited by 1
Factors Contributing to Disability in a Chronic Low Back Pain Population: A Comprehensive Analysis Using Continuous Ambulatory Monitoring
Alschuler, K. N. (2010) · Cited by 1
Present with an Uncertain Future: Dispositional Mindfulness, Covariation Bias, and Event-Related Potential Responses to Emotional Stimuli in Uncertain Contexts
Goodman, R. J. (2014) · VCU Scholars Compass (Virginia Commonwealth University) · doi:10.25772/t2zz-1h21 · Cited by 1
Individual differences in pain and placebo analgesia : the role of fear.
Lyby, P. S. (2012) · NORA - Norwegian Open Research Archives · Cited by 1
ANALGESIC EFFECTS OF EEG ALPHA-WAVE ENTRAINMENT ON ACUTE AND CHRONIC PAIN
Ecsy, K. (2014) · Research Explorer (The University of Manchester) · Cited by 1
Reducing chronic pain using mindfulness meditation: an exploration of the role of spirituality
Mawani, A.-N. (2010) · Mspace (University of Manitoba) · Cited by 1
Desfusão cognitva na Terapia de Aceitação e Compromisso (ACT): o processo de mudança clínica
Assaz, D. A. (2020) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.47.2020.tde-24122021-113814 · Cited by 3
Pain-regulation circuitry as a predictor of chronic pain phenotypesPreprint
Aleali, A., Hashmı, M. A., Friedman, A., Beaupre, I., Cane, D. B., & Hashmi, J. A. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.01.20.699535 · Cited by 2
A Unified Theory of Disorientation
Velasco, P. F. (2021) · theses.fr (ABES) · doi:10.70675/ff433dcfzb3dez4274zba3bz3b69e9b94882 · Cited by 1
An examination of blood oxygen level dependent functional magnetic resonance imaging methods in analysing chronic non-malignant pain patients' responses to non -painful pain stimuli
Taylor, A. (2012) · ORCA Online Research @Cardiff (Cardiff University)
Long-term depression of nociception and pain in man
Jung, K. (2011)
Definition, Pathophysiology, and Assessment of Pain
Eychmüller, S. (2015) · Springer eBooks · doi:10.1007/978-3-662-46202-7_4
Pain Without Power
Lane, T. J. (2008) · PhilPapers (PhilPapers Foundation)
ERP korelati placebo i 'anti-placebo' efekata
Biro, M., Ković, V., Novović, Z., Pejović, J., Sokić, J., & Sovilj, P. (2013) · Primenjena psihologija · doi:10.19090/pp.2013.4.339-354
Magnetoencephalography Characterization of Pain Anticipation in Patients with Post-Stroke Thalamic Pain
Gopalakrishnan, R. (2015) · OhioLink ETD Center (Ohio Library and Information Network)
Long-term depression of nociception and pain in healthy volunteers
Rottmann, S., & Ellrich, J. (2010) · RWTH Publications (RWTH Aachen)
A multi-method approach to understanding pain experience using non-pharmacological interventions that target alpha brain activity
Arendsen, L. J. (2017) · White Rose eTheses Online (University of Leeds, The University of Sheffield, University of York)
Evaluating Quality of Health Care for the Disadvantaged. A Literature Review.
Brook, R. H., & Williams, K. N. (1975) · DigitalGeorgetown (Georgetown University Library)
Changes in interoceptive accuracy in response to social and physical threat
Durlik, C. (2016)
Effects of changes in response expectancy on pain perception and electrophysiology
Almarzouki, A. F. (2015) · Research Explorer (The University of Manchester)
The Impact of Consumer Smart Device Platforms on Illness Uncertainty and Anxiety in Patients with Atrial Fibrillation
Cheung, W. Y. V. (2021) · IRL - University of Missouri, St. Louis (University of Missouri–St. Louis)

Authors: Brown, C. A., Seymour, B., Boyle, Y., El-Deredy, W., & Jones, A. K. P.
Affiliations: University of Manchester (GB)
Wellcome Centre for Human Neuroimaging (GB)
Salford Royal Hospital (GB)
Corresponding author: Brown, Christopher A.
ORCID: Brown, Christopher A.
Seymour, Ben
Jones, Anthony K.P.
Venue: Pain
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2008-04
Volume: 135
Issue: 3
Pages: 240-250
ISSN: 0304-3959 (ISSN-L)
DOI: 10.1016/j.pain.2007.05.022
OpenAlex: W2164512758
Cited by: 218
References: 66
Citations by year: 2026: 9 · 2025: 11 · 2024: 13 · 2023: 16 · 2022: 12 · 2021: 12 · 2020: 15 · 2019: 9 · 2018: 10 · 2017: 17 · 2016: 12 · 2015: 11 · 2014: 13 · 2013: 15 · 2012: 12
FWCI: 3.17
Type: journal article
Language: en
Open access: green
research.manchester.ac.uk
Licence: other-oa
Locations: Pain (publishedVersion)
PubMed (publishedVersion)
Research Explorer (The University of Manchester) (publishedVersion, other-oa)
Cambridge University Engineering Department Publications Database (submittedVersion)
Funders: University of Manchester
Versus Arthritis
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Pain Management and Placebo Effect
Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords: pain anticipation, uncertainty, pain perception, laser-evoked potentials, thermal pain, subjective pain ratings, predictive processing, attentional networks, dorsolateral prefrontal cortex, posterior cingulate cortex, inferior parietal cortex, inferior frontal cortex, inferior temporal cortex, anterior prefrontal cortex, source localization
MeSH terms: Adult, Attention, Behavior, Brain Mapping, Cerebral Cortex, Cognition, Cues, Electroencephalography, Evoked Potentials, Humans, Lasers, Functional Laterality, Memory, Mental Processes, Middle Aged, Nerve Net, Neuropsychological Tests, Pain, Pain Measurement, Physical Stimulation, Pain Threshold, Uncertainty

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Modulation of pain ratings by expectation and uncertainty: Behavioral characteristics and anticipatory neural correlates

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks