The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
TRPA1 receptors mediate environmental irritant-induced meningeal vasodilatation
Open accessAbstract
The TRPA1 receptor is a member of the transient receptor potential (TRP) family of ion channels expressed in nociceptive neurons. TRPA1 receptors are targeted by pungent compounds from mustard and garlic and environmental irritants such as formaldehyde and acrolein. Ingestion or inhalation of these chemical agents causes irritation and burning in the nasal and oral mucosa and respiratory lining. Headaches have been widely reported to be induced by inhalation of environmental irritants, but it is unclear how these agents produce headache. Stimulation of trigeminal neurons releases CGRP and substance P and induces neurogenic inflammation associated with the pain of migraine. Here we test the hypothesis that activation of TRPA1 receptors is the mechanistic link between environmental irritants and peptide-mediated neurogenic inflammation. Known TRPA1 agonists and environmental irritants stimulate CGRP release from dissociated rat trigeminal ganglia neurons and this release is blocked by a selective TRPA1 antagonist, HC-030031. Further, TRPA1 agonists and environmental irritants increase meningeal blood flow following intranasal administration. Prior dural application of the CGRP antagonist, CGRP(8-37), or intranasal or dural administration of HC-030031, blocks the increases in blood flow elicited by environmental irritants. Together these results demonstrate that TRPA1 receptor activation by environmental irritants stimulates CGRP release and increases cerebral blood flow. We suggest that these events contribute to headache associated with environmental irritants.
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Cites
Molecular mechanisms of nociception
Julius, D., & Basbaum, A. I. (2001) · Nature · doi:10.1038/35093019 · Cited by 2,685 · cited 1×
“TRPA1 receptors are often colocalized with the inflammatory peptides substance P and calcitonin gene-related peptide (CGRP) in primary sensory neurons [6,45] and neuronal activation leads to release of these peptides [21] producing neurogenic inflammation and vasodilatation in the dura [31,42].”
Cited by
Mammalian Transient Receptor Potential TRPA1 Channels: From Structure to Disease
Talavera, K., Startek, J. B., Alvarez-Collazo, J., Boonen, B., Alpizar, Y. A., Sanchez, A., Naert, R., & Nilius, B. (2020) · Physiological Reviews · doi:10.1152/physrev.00005.2019 · Cited by 403
Chemosensory properties of the trigeminal system
Viana, F. (2011) · ACS Chemical Neuroscience · doi:10.1021/cn100102c · Cited by 196
Metadata
- Authors
- Kunkler, P. E., Ballard, C. J., Oxford, G. S., & Hurley, J. H.
- Venue
- Pain
- Published
- 2011-01
- Volume
- 152
- Issue
- 1
- Pages
- 38-44
- ISSN
- 0304-3959 (ISSN-L)
- OpenAlex
- W2036724397
- Cited by
- 172
- References
- 1
- FWCI
- 7.38
- Type
- journal article
- Language
- en
- Open access
- green
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- Kunkler, P. E., Ballard, C. J., Oxford, G. S., & Hurley, J. H. (2011). TRPA1 receptors mediate environmental irritant-induced meningeal vasodilatation. Pain. https://doi.org/10.1016/j.pain.2010.08.021
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