The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Influence of cachexia and sarcopenia on survival in pancreatic ductal adenocarcinoma: A systematic review
Open accessAbstract
Background/objectives Cachexia affects ∼ 80% of pancreatic cancer patients. An international consensus defines cachexia as an ongoing loss of skeletal muscle mass (sarcopenia) with or without loss of fat, which impairs body functioning and cannot be reversed by conventional nutritional measures. Weight loss percentage and elevated inflammation markers have been employed to define this condition earlier. This review aimed to assess the prevalence and consequences of cachexia and sarcopenia on survival in patients with pancreatic ductal adenocarcinoma. Methods The systematic review was performed by searching the articles with preset terms published in PubMed and Cochrane Database until December 2013. After identifying relevant titles, abstracts were read and eligible articles data retrieved on preformatted sheets. The prevalence and impact of sarcopenia/cachexia on survival was evaluated. Results In total 1145 articles were retrieved, only 10 were eligible. Definitions of cachexia and sarcopenia were heterogeneous. In patients with normal weight (BMI 18.5-24.9 kg/m(2)) the prevalence of sarcopenia ranged from 29.7 to 65%. In overweight or obese patients (BMI >25 kg/m(2)) were 16.2%-67%. Sarcopenia alone was not demonstrated to be an independent factor of decreased survival, although obese sarcopenic patients were shown to have significantly worse survival in two studies. Conclusions Impact of cachexia and sarcopenia on survival in pancreatic ductal adenocarcinoma is currently understudied in the available literature. Definitive association between cachexia and survival cannot be drawn from available studies, although weight loss and sarcopenic obesity might be considered as poor prognostic factors. Further prospective trials utilizing the consensus definition of cachexia and including other confounding factors are needed to investigate the impact of cachexia and sarcopenia on survival in pancreatic adenocarcinoma.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Indeed, sarcopenia and fat loss are known to be part of a wasting syndrome of pancreatic ductal adenocarcinoma and might have prognostic implications.117,118”
From Early detection of pancreatic cancer (2020) · cites this paper as [117]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Sarcopenia: European consensus on definition and diagnosis
Cruz-Jentoft, A. J., Baeyens, J. P., Bauer, J. M., Boirie, Y., Cederholm, T., Landi, F., Martin, F. C., Michel, J.-P., Rolland, Y., Schneider, S. M., et al. (2010) · Age and Ageing · doi:10.1093/ageing/afq034 · Cited by 11,601
Definition and classification of cancer cachexia: an international consensus
Fearon, K., Strasser, F., Anker, S. D., Bosaeus, I. G., Bruera, E. D., Fainsinger, R. L., Jatoi, A., Loprinzi, C. L., Macdonald, N., Mantovani, G., et al. (2011) · The Lancet Oncology · doi:10.1016/s1470-2045(10)70218-7 · Cited by 6,020
Prado, C. M., Lieffers, J. R., McCargar, L. J., Reiman, T., Sawyer, M. B., Martin, L., & Baracos, V. E. (2008) · The Lancet Oncology · doi:10.1016/s1470-2045(08)70153-0 · Cited by 3,238
Goodpaster, B. H., Park, S. W., Harris, T. B., Kritchevsky, S. B., Nevitt, M., Schwartz, A. V., Simonsick, E. M., Tylavsky, F. A., Visser, M., Newman, A. B., et al. (2006) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/61.10.1059 · Cited by 3,083
Martin, L., Birdsell, L., Macdonald, N., Reiman, T., Clandinin, M. T., McCargar, L. J., Murphy, R. A., Ghosh, S., Sawyer, M. B., & Baracos, V. E. (2013) · Journal of Clinical Oncology · doi:10.1200/jco.2012.45.2722 · Cited by 2,761
Prognostic effect of weight loss prior tochemotherapy in cancer patients
DeWys, W. D., Begg, C. B., Lavin, P. T., Band, P. R., Bennett, J. M., Bertino, J. R., Cohen, M. H., Douglass, H. O., Engstrom, P. F., Ezdinli, E. Z., et al. (1980) · The American Journal of Medicine · doi:10.1016/s0149-2918(05)80001-3 · Cited by 2,350
Evans, W., Morley, J., Argilés, J., Bales, C., Baracos, V., Guttridge, D., Jatoi, A., Kalantar-zadeh, K., Lochs, H., Mantovani, G., et al. (2008) · Clinical Nutrition · doi:10.1016/j.clnu.2008.06.013 · Cited by 2,341
Prado, C. M. M., Baracos, V. E., McCargar, L. J., Reiman, T., Mourtzakis, M., Tonkin, K. S., Mackey, J. R., Koski, S. L., Pituskin, E., & Sawyer, M. B. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-08-2242 · Cited by 1,125
Delmonico, M. J., Harris, T. B., Lee, J., Visser, M., Nevitt, M., Kritchevsky, S. B., Tylavsky, F. A., Newman, A. B., & for the Health, A. A. B. C. S. (2007) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2007.01140.x · Cited by 819
Fearon, K., Voss, A., & Hustead, D. (2006) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/83.6.1345 · Cited by 739
Sarcopenia in an Overweight or Obese Patient Is an Adverse Prognostic Factor in Pancreatic Cancer
Tan, B. H. L., Birdsell, L., Martin, L., Baracos, V. E., & Fearon, K. C. H. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-09-1525 · Cited by 656
Thomas, D. R. (2007) · Clinical Nutrition · doi:10.1016/j.clnu.2007.03.008 · Cited by 521
Baracos, V. E., Reiman, T., Mourtzakis, M., Gioulbasanis, I., & Antoun, S. (2010) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2010.28608c · Cited by 504
Body composition and outcome in patients undergoing resection of colorectal liver metastases19
van Vledder, M. G., Levolger, S., Ayez, N., Verhoef, C. K., Tran, T. C. K., & IJzermans, J. N. M. (2012) · British journal of surgery · doi:10.1002/bjs.7823 · Cited by 464
Antoun, S., Baracos, V. E., Birdsell, L., Escudier, B. J., & Sawyer, M. B. (2010) · Annals of Oncology · doi:10.1093/annonc/mdp605 · Cited by 430
Cachexia Worsens Prognosis in Patients with Resectable Pancreatic Cancer
Bachmann, J., Heiligensetzer, M., Krakowski‐Roosen, H., Büchler, M. W., Friess, H., & Martignoni, M. E. (2008) · Journal of Gastrointestinal Surgery · doi:10.1007/s11605-008-0505-z · Cited by 429
Mir, O., Coriat, R., Blanchet, B., Durand, J.-P., Boudou, P., Michels, J., Ropert, S., Vidal, M., Pol, S., Chaussade, S., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0037563 · Cited by 304
Clinical Survival Predictors in Patients With Advanced Cancer
Vigano, A. A. L., Bruera, E. D., Jhangri, G. S., Newman, S. C., Fields, A. L. A., & Suarez-Almazor, M. E. (2000) · Archives of Internal Medicine · doi:10.1001/archinte.160.6.861 · Cited by 297
Changes in nutritional status associated with unresectable pancreatic cancer.
Wigmore, S., Plester, C., Richardson, R., & Fearon, K. (1997) · British Journal of Cancer · doi:10.1038/bjc.1997.17 · Cited by 252
Dalal, S., Hui, D., Bidaut, L. M., Lem, K. E., Fabbro, E. D., Crane, C. H., Reyes‐Gibby, C. C., Bedi, D. G., & Bruera, E. D. (2012) · Journal of Pain and Symptom Management · doi:10.1016/j.jpainsymman.2011.09.010 · Cited by 186
Sebastiano, K. M. D., Yang, L., Zbuk, K. M., Wong, R. K. W., Chow, T., Koff, D., Moran, G. R., & Mourtzakis, M. (2012) · British Journal Of Nutrition · doi:10.1017/s0007114512001067 · Cited by 137
Pausch, T. M., Hartwig, W., Hinz, U., Swolana, T., Bundy, B. D., Hackert, T., Grenacher, L., Büchler, M. W., & Werner, J. (2012) · Surgery · doi:10.1016/j.surg.2012.05.028 · Cited by 133
Holly, E. A., Chaliha, I., Bracci, P. M., & Gautam, M. (2004) · Clinical Gastroenterology and Hepatology · doi:10.1016/s1542-3565(04)00171-5 · Cited by 133
Performance status of patients is the major prognostic factor at all stages of pancreatic cancer
Taş, F., Şen, F., Odabaş, H., Kılıç, L., Keskın, S., & Yıldız, İ. (2012) · International Journal of Clinical Oncology · doi:10.1007/s10147-012-0474-9 · Cited by 121
Cancer Cachexia: Traditional Therapies and Novel Molecular Mechanism-Based Approaches to Treatment
Kumar, N. B., Kazi, A., Smith, T., Crocker, T., Yu, D., Reich, R. R., Reddy, K. A., Hastings, S., Extermann, M., Balducci, L., et al. (2010) · Current Treatment Options in Oncology · doi:10.1007/s11864-010-0127-z · Cited by 114
Inflammatory burden and amino acid metabolism in cancer cachexia
Durham, W. J., Dillon, E. L., & Sheffield‐Moore, M. (2008) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e32831cef61 · Cited by 110
Body Composition, Symptoms, and Survival in Advanced Cancer Patients Referred to a Phase I Service
Parsons, H. A., Baracos, V. E., Dhillon, N., Hong, D. S., & Kurzrock, R. (2012) · PLoS ONE · doi:10.1371/journal.pone.0029330 · Cited by 97
Miller, B. S., Ignatoski, K. M. W., Daignault, S. D., Lindland, C., Doherty, M., Gauger, P. G., Hammer, G. D., Wang, S. C., & Doherty, G. M. (2012) · World Journal of Surgery · doi:10.1007/s00268-012-1581-5 · Cited by 76
Cachexia and aging: An update based on the fourth international cachexia meeting
Morley, J. E., Anker, S. D., & Evans, W. J. (2009) · The journal of nutrition health & aging · doi:10.1007/s12603-009-0009-x · Cited by 74
Papadoniou, N., Kosmas, C., Gennatas, K., Polyzos, A., Mouratidou, D., Skopelitis, E. E., Tzivras, M., Sougioultzis, S., Papastratis, G., Karatzas, G., et al. (2008) · PubMed · Cited by 53
Cancer Cachexia: From Molecular Mechanisms to Patient's Care
Lucia, S., Esposito, M., Fanelli, F. R., & Muscaritoli, M. (2012) · Critical Reviews™ in Oncogenesis · doi:10.1615/critrevoncog.v17.i3.90 · Cited by 32
Mir, O., Coriat, R., Dhooge, M., Perkins, G., Boudou, P., Brézault, C., Ropert, S., Durand, J.-P., Chaussade, S., & Goldwasser, F. (2012) · Anti-Cancer Drugs · doi:10.1097/cad.0b013e3283556b9b · Cited by 18
Aslani, A., Gill, A. J., ROACH, P. J., Allen, B., & Smith, R. C. (2010) · HPB · doi:10.1111/j.1477-2574.2010.00171.x · Cited by 17
Unresectable pancreatic adenocarcinoma: do we know who survives?
Jamal, M. H., Doi, S. A. R., Simoneau, È., Khalil, J. A., Hassanain, M. M., Chaudhury, P. K., Tchervenkov, J., Metrakos, P. P., & Barkun, J. S. (2010) · HPB · doi:10.1111/j.1477-2574.2010.00220.x · Cited by 16
Cited by
Sorted by citations
Early Detection of Pancreatic Cancer: Opportunities and Challenges
Singhi, A. D., Koay, E. J., Chari, S. T., & Maitra, A. (2019) · Gastroenterology · doi:10.1053/j.gastro.2019.01.259 · Cited by 841
Early detection of pancreatic cancer
Pereira, S. P., Oldfield, L., Ney, A., Hart, P. A., Keane, M. G., Pandol, S. J., Li, D., Greenhalf, W., Jeon, C. Y., Koay, E. J., et al. (2020) · The Lancet Gastroenterology & Hepatology · doi:10.1016/s2468-1253(19)30416-9 · Cited by 482
Gianotti, L. V., Besselink, M. G., Sandini, M., Hackert, T., Conlon, K. C., Gerritsen, A., Griffin, O. M., Fingerhut, A. L., Probst, P., Hilal, M. A., et al. (2018) · Surgery · doi:10.1016/j.surg.2018.05.040 · Cited by 286
Self-citationPrognostic Value of Sarcopenia in Lung Cancer
Yang, M. J., Shen, Y., Tan, L., & Li, W. (2019) · CHEST Journal · doi:10.1016/j.chest.2019.04.115 · Cited by 257
Rollins, K. E., Tewari, N., Ackner, A., Awwad, A., Madhusudan, S., Macdonald, I. A., Fearon, K. C. H., & Lobo, D. N. (2015) · Clinical Nutrition · doi:10.1016/j.clnu.2015.08.005 · Cited by 212
Metadata
- Authors
- Ozola Zalite, I., Zykus, R., Francisco Gonzalez, M., Saygili, F., Pukitis, A., Gaujoux, S., Charnley, R. M., & Lyadov, V.
- Affiliations
- Lithuanian University of Health Sciences (LT)
- Sorbonne Paris Cité (FR)
- Freeman Hospital (GB)
- Ministry of Health of the Russian Federation (RU)
- Corresponding author
- Lyadov, V.
- Venue
- Pancreatology
- Publisher
- Elsevier BV
- Published
- 2015-01
- Volume
- 15
- Issue
- 1
- Pages
- 19-24
- ISSN
- 1424-3903 (ISSN-L)
- OpenAlex
- W2068101666
- Cited by
- 174
- References
- 34
- Citations by year
- 2026: 7 · 2025: 7 · 2024: 15 · 2023: 13 · 2022: 25 · 2021: 25 · 2020: 14 · 2019: 22 · 2018: 17 · 2017: 10 · 2016: 13 · 2015: 6
- FWCI
- 1.13
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- Locations
- Pancreatology (publishedVersion)
- PubMed (publishedVersion)
- Lithuanian University of Health Sciences (submittedVersion)
- RUNA. Repositorio Institucional del Sergas (Servicio Gallego de Salud (SERGAS)) (submittedVersion, other-oa)
- Newcastle University ePrints (Newcastle Univesity)
- Funders
- Educational and Research Program Pancreas 2000
- Topics
- Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
- Health Sciences › Medicine › Oncology › Pancreatic and Hepatic Oncology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Keywords
- cachexia, sarcopenia, pancreatic ductal adenocarcinoma, survival, skeletal muscle mass, sarcopenic obesity, weight loss, obesity, prognostic factors, inflammatory markers
- MeSH terms
- Cachexia, Humans, Pancreatic Neoplasms, Prognosis, Weight Loss, Prevalence, Survival Rate, Carcinoma, Pancreatic Ductal, Sarcopenia
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
