Pathological hypersexuality predominantly linked to adjuvant dopamine agonist therapy in Parkinson's disease and multiple system atrophy
Abstract
Pathological hypersexuality developed in 13 patients with PD and two patients ultimately diagnosed clinically with MSA. Hypersexuality began within 8 months after starting dopamine agonist therapy in 14 of 15 cases, including four on agonist monotherapy. It resolved in the four cases where the agonist was stopped, despite continued levodopa therapy. This was not an isolated behavioral problem in most, with additional compulsive or addictive behaviors coinciding in nine patients (60%). A systematic literature review of pathological hypersexuality in PD revealed similar medication histories; combining these cases with our series, 26 of 29 patients (90%) were on adjuvant dopamine agonists.
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A boost in dopamine levels triggers a search for sexual novelty.
“This suggests that a boost in dopamine levels triggers a search for sexual novelty (Klos et al., 2005;Nakum and Cavanna, 2016;Solla et al., 2015).”
From A motivation model of sex addiction – Relevance to the controversy over the concept (2022) · cites this paper as Klos et al., 2005
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References 14 · Cited by 283
- Authors
- Klos, K. J., Bower, J. H., Josephs, K. A., Matsumoto, J. Y., & Ahlskog, J. E.
- Affiliations
- Mayo Clinic (US)
- Venue
- Parkinsonism & Related Disorders
- Publisher
- Elsevier BV
- Published
- 2005-09
- Volume
- 11
- Issue
- 6
- Pages
- 381-386
- ISSN
- 1353-8020 (ISSN-L)
- OpenAlex
- W1980495418
- Cited by
- 283
- References
- 14
- Citations by year
- 2026: 5 · 2025: 3 · 2024: 5 · 2023: 3 · 2022: 8 · 2021: 9 · 2020: 5 · 2019: 6 · 2018: 5 · 2017: 8 · 2016: 10 · 2015: 13 · 2014: 12 · 2013: 19 · 2012: 16
- FWCI
- 12.96
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Parkinsonism & Related Disorders (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Social Sciences › Psychology › Clinical Psychology › Sexuality, Behavior, and Technology
- Health Sciences › Medicine › Neurology › Neurological disorders and treatments
- Keywords
- dopamine agonist therapy
- MeSH terms
- Pramipexole, Adult, Aged, Antiparkinson Agents, Mental Disorders, Catechols, Humans, Indoles, Levodopa, Male, Middle Aged, Nitriles, Parkinson Disease, Thiazoles, Databases, Factual, Dopamine Agonists, Multiple System Atrophy, Sexual Dysfunctions, Psychological, Benzothiazoles
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