Assessing mobility at home in people with early Parkinson’s disease using an instrumented Timed Up and Go test
Open accessAbstract
Gait and mobility problems are prominent features of Parkinson's Disease (PD), and are difficult to observe clinically in early stages of PD. We previously reported that gait changes were measurable in early to mid-stage PD subjects, when we used inertial sensors during an instrumented Timed Up and Go test (iTUG). With the advent of wearable inertial sensors, home assessment of mobility has become possible. We tested six people with early PD and eight control subjects using the iTUG in the home and laboratory. Our objectives were to 1) investigate the feasibility of testing subjects at home, and 2) compare performance at home versus laboratory. We found that home iTUG testing is feasible and the patients with PD were more affected than the healthy control subjects when tested at home.
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Clinical assessment of motor symptoms is subject to bias from placebo effects, anxiety, or white coat syndrome, where patients apply extra effort and performance does not fully reflect their abilities.
“This clinical assessment is subject to bias from placebo effects, anxiety, or the opposite “white coat syndrome,” where patients apply an extra effort, resulting in a performance that does not fully reflect patients' abilities (107, 108).”
From A Review on Wearable Technologies for Tremor Suppression (2021) · cites this paper as [107]
The Discussion section on comfort at home says that a laboratory setting may increase anxiety and that patients may make extra effort to impress an examiner, potentially making their gait less typical. The study also found that patients with Parkinson’s disease walked more slowly at home than in the laboratory. It does not identify this as “white coat syndrome” or establish placebo effects as a source of assessment bias; its explanation is tentative. (LLM, conf=0.86)
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References 12 · Cited by 103
Research works printed but not linked: 12
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- [2]Zampieri C Salarian A Carlson-Kuhta P Aminian K Nutt JG Horak FB The instrumented Timed Up and Go test: Potential outcome measure for disease modifying therapies in Parkinson’s Disease JNNP 2010 81 171 6 PMC3065923 19726406
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- Authors
- Zampieri, C., Salarian, A., Carlson-Kuhta, P., Nutt, J. G., & Horak, F. B.
- Affiliations
- National Institutes of Health (US)
- Oregon Health & Science University (US)
- Corresponding author
- Zampieri, Cris
- Venue
- Parkinsonism & Related Disorders
- Publisher
- Elsevier BV
- Published
- 2011-05
- Volume
- 17
- Issue
- 4
- Pages
- 277-280
- ISSN
- 1353-8020 (ISSN-L)
- PMC
- PMC2995832
- OpenAlex
- W1994395028
- Cited by
- 103
- References
- 12
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 6 · 2023: 6 · 2022: 4 · 2021: 5 · 2020: 5 · 2019: 7 · 2018: 11 · 2017: 16 · 2016: 6 · 2015: 10 · 2014: 7 · 2013: 7 · 2012: 3
- FWCI
- 10.69
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Parkinsonism & Related Disorders (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Oregon Health and Science University
- Kinetics Foundation
- National Institutes of Health (Z99CL999999, 5r37ag006457-28)
- National Institute on Aging (R37-AG006457, R01AG006457, R01AG019706, AG-006457, P30AG024978, AG024978)
- National Institute of Neurological Disorders and Stroke (R13NS067914, RC1NS068678, R01NS021062)
- National Center for Research Resources (M01RR000334)
- Topics
- Health Sciences › Health Professions › Physical Therapy, Sports Therapy and Rehabilitation › Balance, Gait, and Falls Prevention
- Health Sciences › Medicine › Rehabilitation › Stroke Rehabilitation and Recovery
- Physical Sciences › Engineering › Biomedical Engineering › Gait Recognition and Analysis
- Keywords
- Parkinson's disease, early-stage Parkinson's disease
- MeSH terms
- Biomechanical Phenomena, Female, Humans, Male, Middle Aged, Parkinson Disease, Pilot Projects, Posture, Monitoring, Ambulatory, Gait Disorders, Neurologic
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