Identification of a panel of five serum miRNAs as a biomarker for Parkinson's disease
Abstract
Background and objective Parkinson's disease (PD) is the second most common age-related neurodegenerative disorder after Alzheimer's disease. The aim of this work was to determine whether the differences of serum miRNAs profiling could distinguish PD patients from healthy individuals. Methods We collected serum samples from 106 sporadic PD patients and 91 age/gender-matched healthy controls. Serum miRNAs were analysed by Solexa sequencing followed by a qRT-PCR examination. The qRT-PCR assay, which was divided into two phases, was used to validate the expression of miRNAs screened by Solexa sequencing. Receiver operating characteristic (ROC) curve analysis and clustering analysis were performed to determine the diagnostic usefulness of the selected miRNAs for PD. Results In this study, we generated a profile of 5 serum miRNAs: miR-195 was up-regulated, and miR-185, miR-15b, miR-221 and miR-181a were down-regulated. Conclusion This group of five miRNAs can precisely distinguish PD patients from health individuals and may be used as a potential serum-based biomarker for the diagnosis of PD.
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miR-146a-5p, miR-181a and miR-223 have been implicated in neurodegenerative diseases.
“Consistently, miR-146a-5p, miR-181a and miR-223 have been previously shown to be dysregulated in the CNS, plasma, and/or immune cells of MS patients [36] but also implicated in neurodegenerative diseases [22, 32, 37, 61].”
From Glia-to-neuron transfer of miRNAs via extracellular vesicles: a new mechanism underlying inflammation-induced synaptic alterations (2018) · cites this paper as [22]
Previous evidence indicates that miR-146a-5p, miR-181a and miR-223 are dysregulated in patients affected by neuroinflammatory and neurodegenerative diseases.
“Previous evidence indicates that miR-146a-5p, miR-181a and miR-223 are dysregulated in patients affected by neuroinflammatory [36] and neurodegenerative diseases [22, 37, 60], that are characterized by high production of myeloid EVs [38, 78].”
From Glia-to-neuron transfer of miRNAs via extracellular vesicles: a new mechanism underlying inflammation-induced synaptic alterations (2018) · cites this paper as [22]
Cites
Parkinson’s disease: genetics and pathogenesis
Shulman, J. M., De Jager, P. L., & Feany, M. B. (2011) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-011110-130242 · Cited by 801 · see citing works
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Prada, I., Gabrielli, M., Turola, E., Iorio, A., D’Arrigo, G., Parolisi, R., De Luca, M., Pacifici, M., Bastoni, M., Lombardi, M., et al. (2018) · Acta Neuropathologica · doi:10.1007/s00401-017-1803-x · Cited by 312 · see citing works
- Authors
- Ding, H., Huang, Z., Chen, M., Wang, C., Chen, X., Chen, J., & Zhang, J.
- Venue
- Parkinsonism & Related Disorders
- Publisher
- Elsevier BV
- Published
- 2016-01
- Volume
- 22
- Pages
- 68-73
- ISSN
- 1353-8020
- Cited by
- 167
- References
- 1
- Language
- en
- Funders
- National Natural Science Foundation of China (31170751, 31400671, 31571458, 51173076, 81072329, 81100835)
- Ministry of Education of the People's Republic of China (20130091110037)
- China Postdoctoral Science Foundation (2014M551555, 2015T80536)
- National High-tech Research and Development Program (2014AA020707)
- National Key Research and Development Program of China (2012CB517603)
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