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Comparison of the elevated plus and elevated zero mazes in treated and untreated male Sprague–Dawley rats: Effects of anxiolytic and anxiogenic agents
Open accessAbstract
The elevated plus and zero mazes (Plus and Zero, respectively) are used to assess behavior related to anxiety in rodents but direct comparisons of the two tests are lacking for rats. We compared the two methods in adult male Sprague-Dawley rats. Untreated rats in the Zero spent more time in open zones and exhibited more head dips than in the Plus whereas start latency and closed area entries were lower in the Zero than in the Plus. Diazepam (1 mg/kg) exposure increased time in the open in both mazes. Restraint (60 min prior to testing), yohimbine (2.5 mg/kg), and caffeine (100 mg/kg) had the opposite effect, significantly decreasing time spent in open zones in both mazes. No sexual dimorphism in behavior was seen in either maze in untreated rats. Although more open area time was evident in untreated animals in the Zero, after drug challenge both mazes detected anxiolytic and anxiogenic effects equally. Zero maze data can be analyzed directly because no center region exists; otherwise the two methods appear comparable following challenge.
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Shepherd, J. K., Grewal, S. S., Fletcher, A., Bill, D. J., & Dourish, C. T. (1994) · Psychopharmacology · doi:10.1007/bf02244871 · Cited by 739
The influence of open arm ledges and maze experience in the elevated plus-maze
Fernandes, C., & File, S. E. (1996) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(95)02171-x · Cited by 311
Cited by
Sestakova, N., Puzserova, A., Kluknavsky, M., & Bernatova, I. (2013) · Interdisciplinary Toxicology · doi:10.2478/intox-2013-0020 · Cited by 310
Tests of unconditioned anxiety — Pitfalls and disappointments
Ennaceur, A. (2014) · Physiology & Behavior · doi:10.1016/j.physbeh.2014.05.032 · Cited by 259
Linking emotional valence and anxiety in a mouse insula-amygdala circuit
Nicolas, C., Ju, A., Wu, Y., Eldirdiri, H., Delcasso, S., Couderc, Y., Fornari, C., Mitra, A., Supiot, L., Vérité, A., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-40517-1 · Cited by 107
Ingestion of mycobacterium vaccae decreases anxiety-related behavior and improves learning in mice
Matthews, D. M., & Jenks, S. M. (2013) · Behavioural Processes · doi:10.1016/j.beproc.2013.02.007 · Cited by 105
Rebuli, M. E., Camacho, L., Adonay, M. E., Reif, D. M., Aylor, D. L., & Patisaul, H. B. (2015) · Toxicological Sciences · doi:10.1093/toxsci/kfv163 · Cited by 64
Metadata
- Authors
- Braun, A. A., Skelton, M. R., Vorhees, C. V., & Williams, M. T.
- Venue
- Pharmacology Biochemistry and Behavior
- Publisher
- Elsevier BV
- Published
- 2011-01
- Volume
- 97
- Issue
- 3
- Pages
- 406-415
- ISSN
- 0091-3057 (ISSN-L)
- OpenAlex
- W1970660267
- Cited by
- 197
- References
- 2
- FWCI
- 3.28
- Type
- journal article
- Language
- en
- Open access
- green
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- Braun, A. A., Skelton, M. R., Vorhees, C. V., & Williams, M. T. (2011). Comparison of the elevated plus and elevated zero mazes in treated and untreated male Sprague–Dawley rats: Effects of anxiolytic and anxiogenic agents. Pharmacology Biochemistry and Behavior. https://doi.org/10.1016/j.pbb.2010.09.013
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