Therapeutic potential of GABAB receptor ligands in drug addiction, anxiety, depression and other CNS disorders
Abstract
Glutamate and γ-aminobutyric acid (GABA) are the major excitatory and inhibitory neurotransmitter systems, respectively in the central nervous system (CNS). Dysregulation, in any of these or both, has been implicated in various CNS disorders. GABA acts via ionotropic (GABA(A) and GABA(C) receptor) and metabotropic (GABA(B)) receptor. Dysregulation of GABAergic signaling and alteration in GABA(B) receptor expression has been implicated in various CNS disorders. Clinically, baclofen-a GABA(B) receptor agonist is available for the treatment of spasticity, dystonia etc., associated with various neurological disorders. Moreover, GABAB receptor ligands has also been suggested to be beneficial in various neuropsychiatric and neurodegenerative disorders. The present review is aimed to discuss the role of GABA(B) receptors and the possible outcomes of GABA(B) receptor modulation in CNS disorders.
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A strong link between oxidative stress and anxiety-related phenotypes has been observed.
“In addition, a strong link between oxidative stress and anxiety-related phenotypes has been observed [34].”
From Oxidative Stress Implications in the Affective Disorders: Main Biomarkers, Animal Models Relevance, Genetic Perspectives, and Antioxidant Approaches (2016) · cites this paper as [34]
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References 132 · Cited by 125
- Authors
- Kumar, K., Sharma, S., Kumar, P., & Deshmukh, R.
- Corresponding author
- Deshmukh, Rahul
- Venue
- Pharmacology Biochemistry and Behavior
- Publisher
- Elsevier BV
- Published
- 2013-09
- Volume
- 110
- Pages
- 174-184
- ISSN
- 0091-3057 (ISSN-L)
- OpenAlex
- W1984161481
- Cited by
- 125
- References
- 132
- Citations by year
- 2026: 6 · 2025: 8 · 2024: 8 · 2023: 11 · 2022: 8 · 2021: 12 · 2020: 8 · 2019: 8 · 2018: 13 · 2017: 11 · 2016: 12 · 2015: 11 · 2014: 8
- FWCI
- 1.08
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Pharmacology Biochemistry and Behavior (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Mr. Parveeen Garg
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
- Keywords
- GABAB receptors, GABAergic neurotransmission, baclofen, drug addiction, anxiety, depression, central nervous system disorders, neuropsychiatric disorders, neurodegenerative diseases, GABA receptor modulation, glutamate dysregulation
- MeSH terms
- Anxiety, Central Nervous System Diseases, Depression, gamma-Aminobutyric Acid, Humans, Ligands, Protein Conformation, Receptors, GABA-B, GABA Modulators, Substance-Related Disorders
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