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Cited by 61Neurotransmitter Receptor Influence on BehaviorSubstance Abuse Treatment and OutcomesAlcohol Consumption and Health Effects

Alcohol preferring (P) rats as a model for examining sex differences in alcohol use disorder and its treatment

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Moore, Catherine F., Lynch, Wendy J.·2015·Pharmacology Biochemistry and Behavior
DOI 10.1016/j.pbb.2015.02.014PMC PMC4545742
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Abstract

Rationale Despite epidemiological and clinical data indicating marked gender differences in alcohol use disorders (AUDs), few preclinical studies have examined sex differences in animal models of AUDs. Objective The purpose of this study was to first characterize sex differences in ethanol consumption and reinforcement in an alcohol preferring (P) rat model of alcoholism, then use this model to screen pharmacological treatments for sex-specific effects. Methods Ethanol consumption was first assessed in male and female P rats under a three-bottle free-choice procedure. Next, ethanol's reinforcing effects were assessed under a fixed-ratio 1 (FR1) schedule followed by a progressive-ratio (PR) schedule. Finally, the effects of two pharmacological treatments for AUDs, naltrexone (1mg/kg) and topiramate (10 or 20mg/kg), alone and in combination, were tested for sex-specific differences in their efficacy at reducing ethanol's reinforcing effects. Results Although females initially had higher consumption of and preference for ethanol, male rats increased their consumption and preference over time and rapidly became equal to females. Following prolonged 24-hour/day access, males and females self-administered similar levels of ethanol under FR1 and PR schedules. In response to pharmacological treatment, we observed some sex differences and similarities, most notably, a more robust effect of the combination of naltrexone and topiramate in males as compared to females. Conclusions This model of selectively bred P rats may be useful for understanding sex differences in AUDs and related behavior and their underlying neurobiological mechanisms and treatment.

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  • Selectively bred lines exhibit faster acquisition of alcohol self-administration.

    “Selectively bred lines exhibited the faster acquisition of self-administration (Li and Lumeng, 1984;Moore and Lynch, 2015).”

    From Drug Addiction: Hyperkatifeia/Negative Reinforcement as a Framework for Medications Development (2021) · cites this paper as Moore and Lynch, 2015

    The Introduction says female rats and mice acquire ethanol self-administration more quickly than males, but does not attribute faster acquisition to selectively bred lines. The Methods (§2.4) describe training selectively bred P rats to self-administer ethanol, and the Results (§3.3) report their intake; neither compares their acquisition speed with another line. Searched for faster and rapid acquisition in P rats and selectively bred lines. (LLM, conf=0.74)

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Authors
Moore, C. F., & Lynch, W. J.
Affiliations
University of Virginia (US)
Corresponding author
Lynch, Wendy J.
ORCID
Venue
Pharmacology Biochemistry and Behavior
Publisher
Elsevier BV
Published
2015-05
Volume
132
Pages
1-9
ISSN
0091-3057 (ISSN-L)
DOI
10.1016/j.pbb.2015.02.014
PMC
PMC4545742
OpenAlex
W2089282986
Cited by
61
References
0
Citations by year
2026: 4 · 2025: 6 · 2024: 11 · 2023: 4 · 2022: 4 · 2021: 6 · 2020: 5 · 2019: 2 · 2018: 6 · 2017: 7 · 2016: 5 · 2015: 1
FWCI
2.95
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Pharmacology Biochemistry and Behavior (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
NIAAA (R01AA016554, 5P50AA007611-159005)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
Keywords
alcohol-preferring rats, sex differences, alcoholism, ethanol self-administration, ethanol reinforcement, naltrexone, topiramate, combination pharmacotherapy

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