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Cited by 325Diet and metabolism studiesEpilepsy research and treatmentDietary Effects on Health

The Neuropharmacology of the Ketogenic Diet

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Hartman, Adam L., Gasior, Maciej, Vining, Eileen P.G., Rogawski, Michael A.·2007·Pediatric Neurology
DOI 10.1016/j.pediatrneurol.2007.02.008PMC PMC1940242
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Abstract

The ketogenic diet is a valuable therapeutic approach for epilepsy, one in which most clinical experience has been with children. Although the mechanism by which the diet protects against seizures is unknown, there is evidence that it causes effects on intermediary metabolism that influence the dynamics of the major inhibitory and excitatory neurotransmitter systems in brain. The pattern of protection of the ketogenic diet in animal models of seizures is distinct from that of other anticonvulsants, suggesting that it has a unique mechanism of action. During consumption of the ketogenic diet, marked alterations in brain energy metabolism occur, with ketone bodies partly replacing glucose as fuel. Whether these metabolic changes contribute to acute seizure protection is unclear; however, the ketone body acetone has anticonvulsant activity and could play a role in the seizure protection afforded by the diet. In addition to acute seizure protection, the ketogenic diet provides protection against the development of spontaneous recurrent seizures in models of chronic epilepsy, and it has neuroprotective properties in diverse models of neurodegenerative disease.

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Crossref · 10.1016/j.pediatrneurol.2007.02.008

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  • A ketogenic diet modulates neurotransmitter levels such as GABA, monoamines and glutamate.

    “as well as the modulation of neurotransmitter levels such as GABA, monoamines and glutamate (Hartman et al., 2007;Yudkoff et al., 2008).”

    From The Microbiota-Gut-Brain Axis (2019) · cites this paper as Hartman et al., 2007

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Authors
Hartman, A. L., Gasior, M., Vining, E. P. G., & Rogawski, M. A.
Affiliations
  • National Institutes of Health (US)
  • Johns Hopkins University (US)
Corresponding author
Hartman, Adam L.
ORCID
Venue
Pediatric Neurology
Publisher
Elsevier BV
Published
2007-05
Volume
36
Issue
5
Pages
281-292
ISSN
0887-8994 (ISSN-L)
DOI
10.1016/j.pediatrneurol.2007.02.008
PMC
PMC1940242
OpenAlex
W2144350899
Cited by
325
References
0
Citations by year
2026: 13 · 2025: 16 · 2024: 14 · 2023: 18 · 2022: 17 · 2021: 16 · 2020: 21 · 2019: 18 · 2018: 19 · 2017: 15 · 2016: 22 · 2015: 15 · 2014: 22 · 2013: 11 · 2012: 19
FWCI
1.80
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Pediatric Neurology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health
  • National Institute of Neurological Disorders and Stroke (Z01NS002877)
Topics
  • Health Sciences › Medicine › Physiology › Diet and metabolism studies
  • Health Sciences › Medicine › Psychiatry and Mental health › Epilepsy research and treatment
  • Health Sciences › Medicine › Physiology › Dietary Effects on Health
Keywords
ketogenic diet, epilepsy, anticonvulsant mechanism, brain energy metabolism, ketone bodies, acetone, seizure protection, neuroprotection, neurodegenerative diseases, chronic epilepsy
MeSH terms
Animals, Brain, Child, Epilepsy, Humans, Ketone Bodies, Diet, Carbohydrate-Restricted

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