Influenza A induced acute autonomic neuropathy in an adolescent
Abstract
Influenza A may cause serious neurologic complications, but an autoimmune autonomic ganglionopathy has rarely been reported. Autoantibodies that impair synaptic transmission in the autonomic ganglia may cause orthostatic hypotension, gastrointestinal dysmotility, and sudomotor dysfunction. A 15-year-old girl developed severe and persisting orthostatic hypotension during influenza A infection. Removal of circulating antibodies by a single course of intravenous immunoglobulin resulted in rapid and complete recovery.
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Several post-infectious syndromes have been described, including selective cholinergic dysautonomia with GI dysmotility after infectious mononucleosis (Epstein-Barr virus) or influenza A.
“Several post-infectious syndromes have been described, including selective cholinergic dysautonomia with GI dysmotility after infectious mononucleosis (Epstein-Barr virus) or influenza A (Lukkarinen et al., 2010; Vassallo et al., 1991).”
From Autonomic nervous system and gastrointestinal manifestations with an emphasis on gastric dysfunction (2026) · cites this paper as Lukkarinen et al., 2010
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References 8 · Cited by 11
- Authors
- Lukkarinen, H., & Peltola, V.
- Affiliations
- Turku University Hospital (FI)
- Corresponding author
- Lukkarinen, Heikki
- Venue
- Pediatric Neurology
- Publisher
- Elsevier BV
- Published
- 2010-12
- Volume
- 43
- Issue
- 6
- Pages
- 425-426
- ISSN
- 0887-8994 (ISSN-L)
- OpenAlex
- W2120144909
- Cited by
- 11
- References
- 8
- Citations by year
- 2026: 1 · 2021: 2 · 2019: 1 · 2017: 1 · 2016: 1 · 2014: 1 · 2012: 2
- FWCI
- 0.76
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Pediatric Neurology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Neurology › Peripheral Neuropathies and Disorders
- Health Sciences › Medicine › Neurology › Autoimmune Neurological Disorders and Treatments
- Health Sciences › Medicine › Surgery › Cardiovascular Syncope and Autonomic Disorders
- Keywords
- influenza A virus, autoimmune autonomic ganglionopathy, autonomic neuropathy, orthostatic hypotension, autoantibodies, intravenous immunoglobulin, adolescents, sudomotor dysfunction, gastrointestinal motility disorders
- MeSH terms
- Adolescent, Autonomic Nervous System Diseases, Female, Ganglia, Autonomic, Humans, Influenza, Human, Influenza A virus, Immunoglobulins, Intravenous, Treatment Outcome
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