Effects of hypoglycemia on developmental outcome in children with congenital hyperinsulinism
Abstract
Children with congenital hyperinsulinism are at risk for recurring, severe episodes of hypoglycemia that can cause seizures, brain damage, and developmental delay. To assess the frequency of permanent brain damage in this disorder, we carried out a telephone survey of 68 children who presented to The Children's Hospital of Philadelphia between 1980 and 2000. One third of the group had some degree of developmental delay. Those presenting in the first week of life and those with medically unresponsive hyperinsulinism were more likely to have delays. Early recognition and control of hypoglycemia are essential for preventing developmental delay in these children.
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Early recognition and treatment of congenital hyperinsulinism are crucial for preventing developmental disability.
“Early recognition and treatment are crucial for preventing these sequelae.8–10”
From Recommendations from the Pediatric Endocrine Society for evaluation and management of persistent hypoglycemia in neonates, infants, and children (2015) · cites this paper as [9]
Severe and prolonged hypoglycemia can cause permanent brain injury.
“Whereas recovery from brief periods of hypoglycemia is usually complete, severe and prolonged hypoglycemia can cause permanent brain injury.8–10,16”
From Recommendations from the Pediatric Endocrine Society for evaluation and management of persistent hypoglycemia in neonates, infants, and children (2015) · cites this paper as [9]
The first few months of life are the most vulnerable period for developmental disability.
“Third, the first few months of life are the most vulnerable period for developmental disability, which occurs in ~25%–50% of children with congenital hyperinsulinism.”
From Recommendations from the Pediatric Endocrine Society for evaluation and management of persistent hypoglycemia in neonates, infants, and children (2015) · cites this paper as [9]
Developmental disability occurs in approximately 25%-50% of children with congenital hyperinsulinism.
“Third, the first few months of life are the most vulnerable period for developmental disability, which occurs in ~25%–50% of children with congenital hyperinsulinism.”
From Recommendations from the Pediatric Endocrine Society for evaluation and management of persistent hypoglycemia in neonates, infants, and children (2015) · cites this paper as [9]
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References 31 · Cited by 101
- Authors
- Steinkrauss, L., Lipman, T. H., Hendell, C. D., Gerdes, M., Thornton, P. S., & Stanley, C. A.
- Affiliations
- Children's Hospital of Philadelphia (US)
- Corresponding author
- Steinkrauss, Linda
- Venue
- Journal of Pediatric Nursing
- Publisher
- Elsevier BV
- Published
- 2005-03
- Volume
- 20
- Issue
- 2
- Pages
- 109-118
- ISSN
- 0882-5963 (ISSN-L)
- OpenAlex
- W1988775252
- Cited by
- 101
- References
- 31
- Citations by year
- 2026: 4 · 2024: 7 · 2023: 4 · 2022: 3 · 2021: 10 · 2020: 3 · 2019: 7 · 2018: 12 · 2017: 2 · 2016: 8 · 2015: 7 · 2014: 6 · 2013: 3 · 2012: 2
- FWCI
- 4.41
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Pediatric Nursing (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK056268)
- National Center for Research Resources (M01RR000240)
- Topics
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Metabolism and Genetic Disorders
- Keywords
- congenital hyperinsulinism, hypoglycemia, developmental delay, brain damage, seizures, infants, developmental outcomes
- MeSH terms
- Child, Developmental Disabilities, Child, Preschool, Female, Health Surveys, Hospitals, Pediatric, Humans, Infant, Infant, Newborn, Intelligence Tests, Male, Pediatric Nursing, Surveys and Questionnaires, Risk Factors, Seizures, Philadelphia, Cohort Studies, Incidence, Age Distribution, Brain Injury, Chronic, Nurse's Role, Congenital Hyperinsulinism
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