Metabolism of GIP and the contribution of GIP to the glucose-lowering properties of DPP-4 inhibitors

Deacon, Carolyn F

doi:10.1016/j.peptides.2019.170196

Metabolism of GIP and the contribution of GIP to the glucose-lowering properties of DPP-4 inhibitors

Glucose-dependent insulinotropic polypeptide (GIP) is a gastrointestinal hormone with insulinotropic and glucagonotropic actions, and is believed to be the more physiologically important incretin hormone in healthy humans. Together with the other incretin hormone, glucagon-like peptide-1 (GLP-1),…