Cited by 333Cancer Mechanisms and TherapyComputational Drug Discovery MethodsMetabolism, Diabetes, and Cancer

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Drug repurposing in cancer

Sleire, Linda, Førde, Hilde Elise, Netland, Inger Anne, Leiss, Lina, Skeie, Bente Sandvei, Enger, Per Øyvind·2017·Pharmacological Research

DOI 10.1016/j.phrs.2017.07.013

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Abstract

Cancer is a major health issue worldwide, and the global burden of cancer is expected to increase in the coming years. Whereas the limited success with current therapies has driven huge investments into drug development, the average number of FDA approvals per year has declined since the 1990s. This unmet need for more effective anti-cancer drugs has sparked a growing interest for drug repurposing, i.e. using drugs already approved for other indications to treat cancer. As such, data both from pre-clinical experiments, clinical trials and observational studies have demonstrated anti-tumor efficacy for compounds within a wide range of drug classes other than cancer. Whereas some of them induce cancer cell death or suppress various aspects of cancer cell behavior in established tumors, others may prevent cancer development. Here, we provide an overview of promising candidates for drug repurposing in cancer, as well as studies describing the biological mechanisms underlying their anti-neoplastic effects.

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Authors: Sleire, L., Førde, H. E., Netland, I. A., Leiss, L., Skeie, B. S., & Enger, P. Ø.
Affiliations: University of Bergen (NO)
Haukeland University Hospital (NO)
Corresponding author: Enger, Per Øyvind
ORCID: Leiss, Lina
Skeie, Bente Sandvei
Venue: Pharmacological Research
Publisher: Elsevier BV
Published: 2017-10
Volume: 124
Pages: 74-91
ISSN: 1043-6618 (ISSN-L)
DOI: 10.1016/j.phrs.2017.07.013
OpenAlex: W2734327577
Cited by: 329
References: 333
Citations by year: 2026: 18 · 2025: 21 · 2024: 54 · 2023: 43 · 2022: 45 · 2021: 45 · 2020: 56 · 2019: 24 · 2018: 20 · 2017: 3
FWCI: 4.63
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Pharmacological Research (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer Mechanisms and Therapy
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Drug Discovery › Computational Drug Discovery Methods
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Keywords: drug repurposing, cancer, anticancer agents, FDA-approved drugs, anticancer mechanism, cancer prevention, unmet medical needs, anticancer drug development
MeSH terms: Animals, Antineoplastic Agents, Humans, Neoplasms, Drug Repositioning

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Drug repurposing in cancer

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