The DOI matches its Crossref record; 228 of the 228 references it cites were found in a registry or an index.
Therapeutic targets of oxidative/nitrosative stress and neuroinflammation in ischemic stroke: Applications for natural product efficacy with omics and systemic biology
Abstract
Oxidative/nitrosative stress and neuroinflammation are critical pathological processes in cerebral ischemia-reperfusion injury, and their intimate interactions mediate neuronal damage, blood-brain barrier (BBB) damage and hemorrhagic transformation (HT) during ischemic stroke. We review current progress towards understanding the interactions of oxidative/nitrosative stress and inflammatory responses in ischemic brain injury. The interactions between reactive oxygen species (ROS)/reactive nitrogen species (RNS) and innate immune receptors such as TLR2/4, NOD-like receptor, RAGE, and scavenger receptors are crucial pathological mechanisms that amplify brain damage during cerebral ischemic brain injury. Furthermore, we review the current progress of omics and systematic biology approaches for studying complex network regulations related to oxidative/nitrosative stress and inflammation in the pathology of ischemic stroke. Targeting oxidative/nitrosative stress and neuroinflammation could be a promising therapeutic strategy for ischemic stroke treatment. We then review recent advances in discovering compounds from medicinal herbs with the bioactivities of simultaneously regulating oxidative/nitrosative stress and pro-inflammatory molecules for minimizing ischemic brain injury. These compounds include sesamin, baicalin, salvianolic acid A, 6-paradol, silymarin, apocynin, 3H-1,2-Dithiole-3-thione, (-)-epicatechin, rutin, Dl-3-N-butylphthalide, and naringin. We finally summarize recent developments of the omics and systematic biology approaches for exploring the molecular mechanisms and active compounds of Traditional Chinese Medicine (TCM) formulae with the properties of antioxidant and anti-inflammation for neuroprotection. The comprehensive omics and systematic biology approaches provide powerful tools for exploring therapeutic principles of TCM formulae and developing precision medicine for stroke treatment.
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Cites
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Cited by
Sun, Y.-Y., Zhu, H.-J., Zhao, R.-Y., Zhou, S.-Y., Wang, M.-Q., Yang, Y., & Guo, Z.-N. (2023) · Redox Biology · doi:10.1016/j.redox.2023.102852 · Cited by 279
Reflections of an aging free radical
Halliwell, B. (2020) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2020.10.010 · Cited by 75
MiRNA: Involvement of the MAPK Pathway in Ischemic Stroke. A Promising Therapeutic Target
Gugliandolo, A., Silvestro, S., Sindona, C., Bramanti, P., & Mazzon, E. (2021) · Medicina · doi:10.3390/medicina57101053 · Cited by 49
Wei, L., Li, X., Wei, Q., Chen, L., Xu, L., & Zhou, P. (2023) · Neuroscience · doi:10.1016/j.neuroscience.2023.06.012 · Cited by 3
Metadata
- Authors
- Chen, H., He, Y., Chen, S., Qi, S., & Shen, J.
- Venue
- Pharmacological Research
- Publisher
- Elsevier BV
- Published
- 2020-08
- Volume
- 158
- Pages
- 104877
- ISSN
- 1043-6618 (ISSN-L)
- OpenAlex
- W3024715439
- Cited by
- 282
- References
- 228
- FWCI
- 8.36
- Type
- journal article
- Language
- en
- Open access
- closed
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