Olfactory, partner preference and Fos expression in the vomeronasal projection pathway of sexually sluggish male rats
Abstract
Sexually sluggish (S) male rats take a long time to ejaculate or sometimes they don't achieve ejaculation when tested on repeated occasions with receptive females. In order to further understand what factors might contribute to the inconsistent display of sexual behavior in these animals and determine if S and non-copulating males have a different neurobiological profile, the present study was design to characterize sex-related behaviors of S male rats. We tested their preference to physically interact between a sexually receptive female and a sexually active male. We also tested whether S males have a preference to investigate soiled bedding from females in estrous, anestrous or clean bedding. We also evaluated if the serum hormonal levels of testosterone (T) and estradiol (E) are different between copulating (C) and S male rats. Finally, we compared the neuronal activity of the vomeronasal projection pathway of C and S male rats exposed to estrous bedding. The results indicate that S male rats increased the percentage of animals displaying mounts and intromissions after repeated testing with receptive females but no increased was observed in the percentage of animals displaying ejaculations (a total of nine tests were performed). Both C and S males had a clear preference to interact with a sexually receptive female. Both groups showed a clear preference for bedding from estrous females as opposed to anestrous or clean bedding. However, the time investigating the estrous bed…
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Around 40% of BARR and ISO males did not ejaculate in either test of copulatory behavior, a significant deviation from CTRL males (12.5%) and from the expected distribution of non-ejaculators (~10%).
“Around 40% of BARR and ISO males did not ejaculate in either test of copulatory behavior, a significant deviation from what was seen in CTRL males (12.5%) and from the expected distribution of non-ejaculators (~10%) based on decades of research on male rat sexual behavior (Dewsbury, 1972; Pattij et al., 2005; Portillo et al., 2006).”
From Social play experience in juvenile rats is indispensable for appropriate socio-sexual behavior in adulthood in males but not females (2023) · cites this paper as Portillo et al., 2006
The expected distribution for control animals is 90% ejaculators and 10% non-ejaculators/duds.
“the expected distribution (90% ejaculators, 10% non-ejaculators/“duds”)”
From Social play experience in juvenile rats is indispensable for appropriate socio-sexual behavior in adulthood in males but not females (2023) · cites this paper as Portillo et al., 2006
Around 10% of all sexually mature male rats are duds (sexually sluggish), meaning that they do not ejaculate in the course of a 20-30 min assay with a sexually receptive female.
“It is well known in the field of rodent sexual behavior that around 10% of all sexually mature male rats will be “duds” (otherwise known as “sexually sluggish”), meaning that they do not ejaculate in the course of a 20–30 min assay with a sexually receptive female (Dewsbury, 1972; Pattij et al., 2005; Portillo et al., 2006).”
From Social play experience in juvenile rats is indispensable for appropriate socio-sexual behavior in adulthood in males but not females (2023) · cites this paper as Portillo et al., 2006
Cites
Pattij, T., De Jong, T. R., Uitterdijk, A., Waldinger, M. D., Veening, J. G., Cools, A. R., Van Der Graaf, P. H., & Olivier, B. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04252.x · Cited by 163 · see citing works
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Marquardt, A. E., VanRyzin, J. W., Fuquen, R. W., & McCarthy, M. M. (2023) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2022.1076765 · Cited by 31 · see citing works
“It is well known in the field of rodent sexual behavior that around 10% of all sexually mature male rats will be “duds” (otherwise known as “sexually sluggish”), meaning that they do not ejaculate in the course of a 20–30 min assay with a sexually receptive female (Dewsbury, 1972; Pattij et al., 2005; Portillo et al.,…”
Background
- Authors
- PORTILLO, W., DIAZ, N., RETANAMARQUEZ, S., & PAREDES, R.
- Affiliations
- Universidad Nacional Autónoma de México (MX)
- Corresponding author
- PAREDES, R
- Venue
- Physiology & Behavior
- Publisher
- Elsevier BV
- Published
- 2006-07-30
- Volume
- 88
- Issue
- 4-5
- Pages
- 389-397
- ISSN
- 0031-9384 (ISSN-L)
- OpenAlex
- W1963597864
- Cited by
- 26
- References
- 1
- Citations by year
- 2023: 2 · 2022: 1 · 2020: 2 · 2018: 1 · 2016: 2 · 2015: 3 · 2014: 2 · 2013: 3 · 2012: 1
- FWCI
- 0.72
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Physiology & Behavior (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Consejo Nacional de Ciencia y Tecnología
- Dirección General de Asuntos del Personal Académico, Universidad Nacional Autónoma de México
- Topics
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Health Sciences › Medicine › Psychiatry and Mental health › Sexual function and dysfunction studies
- Keywords
- male sexual behavior, mate preferences, Fos expression, olfactory cues, testosterone, estradiol, copulation
- MeSH terms
- Animals, Ejaculation, Estrogens, Female, Male, Neural Pathways, Neurons, Sexual Behavior, Animal, Smell, Testosterone, Genes, fos, Rats, Wistar, Vomeronasal Organ, Estrous Cycle, Rats
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