Vasopressin facilitates play fighting in juvenile golden hamsters
Abstract
Vasopressin facilitates aggression in adult hamsters. Whether this neuropeptide has a similar role in play fighting remains unknown. The goal of the present study was to identify whether vasopressin controls play fighting in juvenile golden hamsters as well. Juvenile male golden hamsters were tested for play fighting after microinjections of a vasopressin V1A-receptor antagonist, Manning compound, either 0, 9, or 90 microM, into the anterior hypothalamus. The treatment selectively inhibited offensive aspects of play fighting in experimental animals. Attack frequencies were significantly decreased by both doses of Manning compound. In addition, the high dose of the receptor antagonist increased attack latencies, decreased bite frequencies, and decreased the averaged number of attacks per contact bout. Together, these results show that vasopressin controls offensive behaviors throughout development from play fighting in juveniles to aggression in adults.
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The LS plays a critical role in juvenile social play behavior in rats and hamsters.
“More specifically, the LS plays a critical role in juvenile social play behavior as demonstrated in both rats and hamsters (Beatty et al., 1982;Cheng & Delville, 2009;Veenema et al., 2013, Bredewold et al., 2014, 2015).”
From Vasopressin regulates social play behavior in sex-specific ways through glutamate modulation in the lateral septum (2025) · cites this paper as Cheng & Delville, 2009
V1aR antagonists influence levels of play fighting in juvenile hamsters and rats, but the direction depends on sex and brain area injected.
“Studies in our and other laboratories have demonstrated that AVP 1a receptor (V1aR) antagonists influence levels of play fighting in juvenile hamsters and rats (Cheng and Delville, 2009; Veenema et al., 2013), but the direction of these effects depends upon the sex of the subject and brain area injected.”
From Sexually dimorphic role for vasopressin in the development of social play (2014) · cites this paper as Cheng and Delville, 2009
AVP has been implicated in juvenile social play.
“While AVP has been implicated in juvenile social play (Cheng and Delville, 2009; Veenema et al., 2013)”
From Sexually dimorphic role for vasopressin in the development of social play (2014) · cites this paper as Cheng and Delville, 2009
V1aR blockade in the anterior hypothalamus decreased the number of attacks and bites during social play in juvenile male hamsters.
“Furthermore, V1aR blockade in the anterior hypothalamus (which is a possible projection site of AVP cells in the nucleus circularis and SON; Cheng et al., 2008) decreased the number of attacks and bites during social play in juvenile male hamsters (Cheng & Delville, 2009).”
From Sex-specific modulation of juvenile social play by vasopressin (2013) · cites this paper as Cheng & Delville, 2009
In juvenile golden hamsters, microinjections of a V1AR antagonist into the anterior hypothalamus inhibited social play behavior.
“Cheng and Delville (2009) showed that in juvenile golden hamsters, microinjections of a V1AR antagonist into the AH inhibited social play behavior.”
From Quantitative mapping reveals age and sex differences in vasopressin, but not oxytocin, immunoreactivity in the rat social behavior neural network (2017) · cites this paper as Cheng and Delville (2009)
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The pleasures of play: pharmacological insights into social reward mechanisms
Trezza, V., Baarendse, P. J. J., & Vanderschuren, L. J. M. J. (2010) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2010.06.008 · Cited by 372 · see citing works
The neurobiology of social play and its rewarding value in rats
Vanderschuren, L. J. M. J., Achterberg, E. J. M., & Trezza, V. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.07.025 · Cited by 329 · see citing works
Sex-specific modulation of juvenile social play by vasopressin
Veenema, A. H., Bredewold, R., & De Vries, G. J. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.06.002 · Cited by 166 · see citing works
“Furthermore, V1aR blockade in the anterior hypothalamus (which is a possible projection site of AVP cells in the nucleus circularis and SON; Cheng et al., 2008) decreased the number of attacks and bites during social play in juvenile male hamsters (Cheng & Delville, 2009).”
BackgroundDiBenedictis, B. T., Nussbaum, E. R., Cheung, H. K., & Veenema, A. H. (2017) · Journal of Comparative Neurology · doi:10.1002/cne.24216 · Cited by 74 · see citing works
“Along these lines, Cheng and Delville (2009) showed that in juvenile golden hamsters, microinjections of a V1AR antagonist into the AH inhibited social play behavior.”
BackgroundThe neurobiology of social play behaviour: Past, present and future
Achterberg, E. J. M., & Vanderschuren, L. J. M. J. (2023) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2023.105319 · Cited by 56 · see citing works
Sexually dimorphic role for vasopressin in the development of social play
Paul, M. J., Terranova, J. I., Probst, C. K., Murray, E. K., Ismail, N. I., & de Vries, G. J. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00058 · Cited by 51 · see citing works
Bredewold, R., Washington, C., & Veenema, A. H. (2025) · Neuropsychopharmacology · doi:10.1038/s41386-024-01987-z · Cited by 13 · see citing works
- Authors
- Cheng, S.-Y., & Delville, Y.
- Affiliations
- The University of Texas at Austin (US)
- Corresponding author
- Cheng, Shao-Ying
- ORCID
- Delville, Yvon
- Venue
- Physiology & Behavior
- Publisher
- Elsevier BV
- Published
- 2009-08
- Volume
- 98
- Issue
- 1-2
- Pages
- 242-246
- ISSN
- 0031-9384 (ISSN-L)
- OpenAlex
- W1995685760
- Cited by
- 30
- References
- 0
- Citations by year
- 2024: 2 · 2023: 2 · 2022: 1 · 2020: 2 · 2019: 3 · 2018: 4 · 2017: 1 · 2016: 2 · 2015: 1 · 2014: 3 · 2013: 3 · 2012: 2
- FWCI
- 2.60
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Physiology & Behavior (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Science Foundation
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- vasopressin, play fighting, V1a receptor, anterior hypothalamus, aggression, offensive behavior, attack latency, behavioral development
- MeSH terms
- Aggression, Agonistic Behavior, Animals, Arginine Vasopressin, Data Interpretation, Statistical, Cricetinae, Hypothalamus, Anterior, Male, Mesocricetus, Microinjections, Preoptic Area, Vasopressins, Antidiuretic Hormone Receptor Antagonists
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