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Cited by 123Stress Responses and CortisolNeuroendocrine regulation and behaviorMemory and Neural Mechanisms

Isolation rearing attenuates social interaction-induced expression of immediate early gene protein products in the medial prefrontal cortex of male and female rats

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Wall, Vanessa L., Fischer, Eva K., Bland, Sondra T.·2012·Physiology & Behavior
DOI 10.1016/j.physbeh.2012.09.002PMC PMC4529065
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Abstract

Early life adversity and stress in humans have been related to a number of psychological disorders including anxiety, depression, and addiction. The present study used isolation rearing, a well-characterized animal model of early life adversity, to examine its effects on social behavior and immediate early gene (IEG) expression produced by exposure to a novel social experience. Male and female rats were housed in same-sex groups or in isolation for 4 weeks beginning at weaning and were tested during late adolescence. The protein products of the IEGs c-fos and Arc, as well as the neurotrophic factor BDNF were assessed in medial prefrontal cortex (mPFC) subregions (anterior cingulate, prelimbic and infralimbic) using immunohistochemistry. Aggressive and non-aggressive behaviors during novel social exposure were also assessed. Exposure to a novel conspecific produced increases in Arc and c-fos activation in the mPFC of group reared animals in a sex- and subregion-dependent fashion compared to no social exposure controls, but this increase was blunted or absent in isolated animals. Isolates engaged in more social interactions and more aggressive behavior than group reared rats. Sex differences in some behaviors as well as in Arc and BDNF expression were observed. These results indicate that isolation rearing alters IEG activation in the mPFC produced by exposure to a novel conspecific, in addition to changing social behavior, and that these effects depend in part on sex.

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Authors
Wall, V. L., Fischer, E. K., & Bland, S. T.
Affiliations
  • University of Colorado Denver (US)
  • Colorado State University (US)
Corresponding author
Bland, Sondra T.
ORCID
Venue
Physiology & Behavior
Publisher
Elsevier BV
Published
2012-10
Volume
107
Issue
3
Pages
440-450
ISSN
0031-9384 (ISSN-L)
DOI
10.1016/j.physbeh.2012.09.002
PMC
PMC4529065
OpenAlex
W2072361337
Cited by
123
References
76
Citations by year
2026: 4 · 2025: 7 · 2024: 11 · 2023: 10 · 2022: 3 · 2021: 10 · 2020: 11 · 2019: 6 · 2018: 9 · 2017: 15 · 2016: 9 · 2015: 13 · 2014: 10 · 2013: 5
FWCI
3.75
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Physiology & Behavior (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • NARSAD Young Investigator Award (STB)
  • NIH (R03DA029673)
Topics
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords
isolation rearing, childhood adversity, immediate early gene expression, medial prefrontal cortex, c-fos, Arc, brain-derived neurotrophic factor, social interaction, social aggression, sex differences, adolescent social behavior
MeSH terms
Analysis of Variance, Animals, Cell Count, Female, Gene Expression Regulation, Interpersonal Relations, Male, Motor Activity, Muscle Proteins, Sex Characteristics, Social Isolation, Statistics as Topic, Proto-Oncogene Proteins c-fos, Rats, Sprague-Dawley, Prefrontal Cortex, Immediate-Early Proteins, Brain-Derived Neurotrophic Factor, Apoptosis Regulatory Proteins, Rats

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