Epigenetics: The DNA Methylation Profile of Tissue-Dependent and Differentially Methylated Regions in Cells
Abstract
Methylation of DNA, which occurs at cytosines of CpG sequences, is a unique chemical modification of the vertebrate genome. Methylation patterns can be copied to daughter DNA after mitosis; thus DNA methylation has been suggested to act as a "cellular memory of the genome function". Genome-wide analysis of DNA methylation revealed that there are numerous tissue-dependent differentially methylated regions (T-DMRs) in unique sequences of the mammalian genome. There are T-DMRs in both CpG-rich and -poor sequences. Methylation of T-DMRs is responsible for gene-silencing and chromatin structure change. Each tissue/cell type has a unique DNA methylation profile that consists of methylation patterns of numerous loci in the genome. DNA methylation profiles are not associated with bulk DNA, which is mainly comprised of repetitive sequences. Disruption of DNA methylation profiles putatively produce abnormal cells and tissues. Cloned mice produced by somatic nuclear transfer are associated with aberrant DNA methylation profiles. Tissue/cell type-specific DNA methylation profiles can provide a novel viewpoint for understanding normal and aberrant development, in terms of both differentiation and reproduction.
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DNA methylation plays crucial roles in gene-silencing events, particularly at the promoter regions of genes, and varies per tissue type.
“DNA methylation plays crucial roles in gene-silencing events, particularly at the promoter regions of genes, and varies per tissue type (Ohgane et al., 2008).”
From The Epigenetics of Anxiety Pathophysiology: A DNA Methylation and Histone Modification Focused Review (2023) · cites this paper as Ohgane et al., 2008
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Miller, G. E., Chen, E., & Parker, K. J. (2011) · Psychological Bulletin · doi:10.1037/a0024768 · Cited by 1,785 · see citing works
Persaud, N. S., & Cates, H. M. (2023) · eneuro · doi:10.1523/eneuro.0109-21.2021 · Cited by 41 · see citing works
“DNA methylation plays crucial roles in gene-silencing events, particularly at the promoter regions of genes, and varies per tissue type (Ohgane et al., 2008).”
Background
- Authors
- Ohgane, J., Yagi, S., & Shiota, K.
- Affiliations
- The University of Tokyo (JP)
- National Institute of Advanced Industrial Science and Technology (JP)
- Corresponding author
- Shiota, K.
- ORCID
- Yagi, S.
- Venue
- Placenta
- Publisher
- Elsevier BV
- Published
- 2008-03
- Volume
- 29
- Pages
- 29-35
- ISSN
- 0143-4004 (ISSN-L)
- OpenAlex
- W2030960893
- Cited by
- 111
- References
- 0
- Citations by year
- 2026: 1 · 2025: 6 · 2024: 4 · 2023: 3 · 2022: 4 · 2021: 6 · 2020: 8 · 2019: 5 · 2018: 1 · 2017: 4 · 2016: 9 · 2015: 4 · 2014: 10 · 2013: 15 · 2012: 11
- FWCI
- 0.38
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Placenta (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Syndromes and Imprinting
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Keywords
- DNA methylation, differentially methylated regions, CpG methylation, gene silencing, chromatin structure, cloned mice, aberrant methylation, cellular memory, development (biology), reproduction, cell differentiation
- MeSH terms
- Animals, Female, Gene Expression Regulation, Humans, Placenta, Pregnancy, DNA Methylation, Epigenesis, Genetic
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