Hydrogen sulfide producing enzymes in pregnancy and preeclampsia
Open accessAbstract
Preeclampsia, a human pregnancy specific disorder is characterized by an anti-angiogenic state. As hydrogen sulfide (H(2)S) has pro-angiogenic and anti-oxidative characteristics, we hypothesized that H(2)S levels could play a role in the pathogenesis of preeclampsia and studied the placental expression of the H(2)S-producing enzymes cystathionine-γ-lyase (CSE) and cystathionine-β-synthase (CBS). CBS and CSE protein are expressed in the fetal-placental endothelium and CBS only in Hofbauer cells. CBS mRNA expression is decreased (p = 0.002) in early-onset preeclampsia, while CSE mRNA is unchanged. Thus, down regulation of CBS during early-onset preeclampsia may result in less H(2)S-production and may aid in the anti-angiogenic state.
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CBS and CSE have been immunolocalized to the syncytiotrophoblast and also to the smooth muscle cells surrounding the stem villus arteries in the human placenta.
“CBS and CSE have been immunolocalized to the syncytiotrophoblast and also to the smooth muscle cells surrounding the stem villus arteries in the human placenta (111, 262).”
From Placental Origins of Chronic Disease (2016) · cites this paper as [262]
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References 25 · Cited by 86
- Authors
- Holwerda, K. M., Bos, E. M., Rajakumar, A., Ris-Stalpers, C., van Pampus, M. G., Timmer, A., Erwich, J. J. H. M., Faas, M. M., van Goor, H., & Lely, A. T.
- Affiliations
- University Medical Center Groningen (NL)
- Beth Israel Deaconess Medical Center (US)
- Corresponding author
- Holwerda, K.M.
- Venue
- Placenta
- Publisher
- Elsevier BV
- Published
- 2012-06
- Volume
- 33
- Issue
- 6
- Pages
- 518-521
- ISSN
- 0143-4004 (ISSN-L)
- OpenAlex
- W1984409894
- Cited by
- 86
- References
- 25
- Citations by year
- 2026: 2 · 2025: 9 · 2024: 6 · 2023: 4 · 2022: 4 · 2021: 7 · 2020: 8 · 2019: 7 · 2018: 2 · 2017: 8 · 2016: 10 · 2015: 8 · 2014: 2 · 2013: 9
- FWCI
- 7.29
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Placenta (publishedVersion)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (publishedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
- Funders
- Dutch Kidney Foundation (KBSO 11.014)
- University Medical Center Groningen
- Groningen University Institute of Drug Exploration
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Sulfur Compounds in Biology
- Health Sciences › Medicine › Psychiatry and Mental health › Neurological Complications and Syndromes
- Keywords
- hydrogen sulfide, preeclampsia, cystathionine gamma-lyase, cystathionine beta-synthase, Hofbauer cells, angiogenesis, early-onset preeclampsia, gene expression, oxidative stress
- MeSH terms
- Adult, Cystathionine beta-Synthase, Cystathionine gamma-Lyase, Female, Humans, Hydrogen Sulfide, Pre-Eclampsia, Pregnancy, RNA, Messenger, Down-Regulation
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