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Cited by 271Pregnancy and preeclampsia studiesReproductive System and PregnancyBirth, Development, and Health

The Human Placenta Project: Placental structure, development, and function in real time

Open access
Guttmacher, A.E., Maddox, Y.T., Spong, C.Y.·2014·Placenta
DOI 10.1016/j.placenta.2014.02.012PMC PMC3999347
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Abstract

Despite its crucial role in the health of both the fetus and the pregnant woman, the placenta is the least understood human organ. Since a growing body of evidence also underscores the importance of placental development in the lifelong health of both mother and offspring, this lack of knowledge about placental structure and function is particularly concerning. Given modern approaches and technologies and the ability to develop new methods, we propose a coordinated "Human Placenta Project", with the ultimate goal of understanding human placental structure, development, and function in real time.

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Crossref · 10.1016/j.placenta.2014.02.012

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  • Existing assessments remain organ-specific, neglecting the dynamic interplay between placental perfusion and pulmonary surfactant synthesis.

    “First, assessments remain organ-specific, neglecting the dynamic interplay between placental perfusion and pulmonary surfactant synthesis (9).”

    From Placenta-pulmonary coupling-guided multimodal AI for fetal lung maturity staging and individualized glucocorticoid therapy (2026) · cites this paper as [9]

    The Abstract says existing placental assessments rely largely on post-delivery examination and calls for monitoring placental function in real time. It does not say assessments are organ-specific or discuss an interplay between placental perfusion and pulmonary surfactant synthesis. (LLM, conf=0.83)

    Experimental — accuracy not yet measured

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References 23 · Cited by 271

Research works printed but not linked: 22

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Authors
Guttmacher, A. E., Maddox, Y. T., & Spong, C. Y.
Affiliations
National Institutes of Health (US)
Corresponding author
Spong, C.Y.
Venue
Placenta
Publisher
Elsevier BV
Published
2014-05
Volume
35
Issue
5
Pages
303-304
ISSN
0143-4004 (ISSN-L)
DOI
10.1016/j.placenta.2014.02.012
PMC
PMC3999347
OpenAlex
W2113103631
Cited by
271
References
23
Citations by year
2026: 18 · 2025: 17 · 2024: 24 · 2023: 26 · 2022: 30 · 2021: 16 · 2020: 22 · 2019: 28 · 2018: 21 · 2017: 24 · 2016: 14 · 2015: 22 · 2014: 8 · 2013: 1
FWCI
23.07
Type
journal article
Language
en
Open access
Licence
Locations
  • Placenta (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institutes of Health (Z99HD999999)
Topics
  • Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
  • Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
Keywords
human placenta, placental development, placental structure, placental function, fetal well-being, maternal health, lifelong health, real-time imaging, research coordination
MeSH terms
Female, Humans, Maternal-Fetal Exchange, Placenta, Placentation, Pregnancy

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