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Regulation of antioxidant defense and glyoxalase systems in cyanobacteria
Abstract
Oxidative stress is common consequence of abiotic stress in plants as well as cyanobacteria caused by generation of reactive oxygen species (ROS), an inevitable product of respiration and photosynthetic electron transport. ROS act as signalling molecule at low concentration however, when its production exceeds the endurance capacity of antioxidative defence system, the organisms suffer oxidative stress. A highly toxic metabolite, methylglyoxal (MG) is also produced in cyanobacteria in response to various abiotic stresses which consequently augment the ensuing oxidative damage. Taking recourse to the common lineage of eukaryotic plants and cyanobacteria, it would be worthwhile to explore the regulatory role of glyoxalase system and antioxidative defense mechanism in combating abiotic stress in cyanobacteria. This review provides comprehensive information on the complete glyoxalase system (GlyI, GlyII and GlyIII) in cyanobacteria. Furthermore, it elucidates the recent understanding regarding the production of ROS and MG, noteworthy link between intracellular MG and ROS and its detoxification via synchronization of antioxidants (enzymatic and non-enzymatic) and glyoxalase systems using glutathione (GSH) as common co-factor.
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“Furthermore, malondialdehyde (MDA) contents serve as a key biomarker of oxidative injury in microalgal cell membranes, which are rich in polyunsaturated fatty acids prone to oxidation (Rai et al. 2021).”
From Integrated morpho-physiological and biochemical description of the mechanisms leading stress responses in cyanobacteria (Arthrospira platensis) upon exposure to Erythromycin (2025) · cites this paper as Rai et al. 2021
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Metadata
- Authors
- Rai, R., Singh, S., Rai, K. K., Raj, A., Sriwastaw, S., & Rai, L. C.
- Affiliations
- Banaras Hindu University (IN)
- Corresponding author
- Rai, L.C.
- Venue
- Plant Physiology and Biochemistry
- Publisher
- Elsevier BV
- Published
- 2021-11
- Volume
- 168
- Pages
- 353-372
- ISSN
- 0981-9428 (ISSN-L)
- OpenAlex
- W3205425525
- Cited by
- 51
- References
- 309
- Citations by year
- 2026: 5 · 2025: 15 · 2024: 14 · 2023: 11 · 2022: 6
- FWCI
- 0.74
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Plant Physiology and Biochemistry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Stress Responses and Tolerance
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Photosynthetic Processes and Mechanisms
- Keywords
- cyanobacteria, oxidative stress, reactive oxygen species, methylglyoxal, glyoxalase system, antioxidant defense, glutathione, abiotic stress, glyoxalase I, glyoxalase II, detoxification
- MeSH terms
- Cyanobacteria, Antioxidants, Plants, Pyruvaldehyde, Reactive Oxygen Species
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