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Cited by 236Autism Spectrum Disorder ResearchAntioxidant Activity and Oxidative StressChild Nutrition and Feeding Issues

The DOI matches its Crossref record; 43 of the 44 references it cites were found in a registry or an index.

Increased excretion of a lipid peroxidation biomarker in autism

Ming, X., Stein, T.P., Brimacombe, M., Johnson, W.G., Lambert, G.H., Wagner, G.C.·2005·Prostaglandins, Leukotrienes and Essential Fatty Acids
DOI 10.1016/j.plefa.2005.06.002
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Abstract

It is thought that autism could result from an interaction between genetic and environmental factors with oxidative stress as a potential mechanism linking the two. One genetic factor may be altered oxidative-reductive capacity. This study tested the hypothesis that children with autism have increased oxidative stress. We evaluated children with autism for the presence of two oxidative stress biomarkers. Urinary excretion of 8-hydroxy-2-deoxyguanosine (8-OHdG) and 8-isoprostane-F2alpha (8-iso-PGF2alpha) were determined in 33 children with autism and 29 healthy controls. 8-iso-PGF2alpha levels were significantly higher in children with autism. The isoprostane levels in autistic subjects were variable with a bimodal distribution. The majority of autistic subjects showed a moderate increase in isoprostane levels while a smaller group of autistic children showed dramatic increases in their isoprostane levels. There was a trend of an increase in 8-OHdG levels in children with autism but it did not reach statistical significance. There was no significant correlation between the levels of the biomarkers and vitamin intake, dietary supplements, medicine, medical disorders, or history of regression. These results suggest that the lipid peroxidation biomarker is increased in this cohort of autistic children, especially in the subgroup of autistic children.

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Research works printed but not linked: 3

  1. Golse, 1978, Perturbation de deux enzymes; la superoxyde-dismutase I et la glutathione-peroxydase dans la psychose infantile de developpement (autisme infantile), Rev. Neurol. (Paris), 134, 699
  2. D. Shaffer, M. Campbell, S.J. Bradley, D.P. Cantwell, G.A. Carlson, D.J. Cohen, et al., Diagnostic and Statistical Manual of Mental Disorders, fourth ed., American Psychiatric Association, Washington, DC, 1994, pp. 65–78.
  3. Stein, 1996, nitrogen metabolism during spaceflight on the shuttle, J. Appl. Physiol., 81, 82, 10.1152/jappl.1996.81.1.82 · DOI

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Metadata

Authors
Ming, X., Stein, T. P., Brimacombe, M., Johnson, W. G., Lambert, G. H., & Wagner, G. C.
Affiliations
  • Rutgers, The State University of New Jersey (US)
  • Rutgers New Jersey Medical School (US)
Corresponding author
Ming, X.
ORCID
Venue
Prostaglandins, Leukotrienes and Essential Fatty Acids
Publisher
Elsevier BV
Published
2005-11
Volume
73
Issue
5
Pages
379-384
ISSN
0952-3278 (ISSN-L)
DOI
10.1016/j.plefa.2005.06.002
OpenAlex
W2113611591
Cited by
236
References
44
Citations by year
2025: 9 · 2024: 7 · 2023: 2 · 2022: 4 · 2021: 10 · 2020: 6 · 2019: 9 · 2018: 13 · 2017: 11 · 2016: 12 · 2015: 11 · 2014: 18 · 2013: 16 · 2012: 9
FWCI
5.79
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Prostaglandins Leukotrienes and Essential Fatty Acids (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5r21ns043981-03)
  • National Institute of Neurological Disorders and Stroke (NS 43981)
  • National Institute of Environmental Health Sciences (ES 11256, ES-05022., P01ES011256, P30ES005022)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
  • Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
  • Health Sciences › Medicine › Psychiatry and Mental health › Child Nutrition and Feeding Issues
Keywords
autism spectrum disorder, oxidative stress, lipid peroxidation, 8-isoprostane, 8-hydroxy-2'-deoxyguanosine, urinary biomarkers, children, gene-environment interaction
MeSH terms
8-Hydroxy-2'-Deoxyguanosine, Adolescent, Autistic Disorder, Child, Child, Preschool, Deoxyguanosine, Female, Humans, Male, Lipid Peroxidation, Dinoprost, Cohort Studies, Biomarkers, Oxidative Stress

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