Aging of human muscle: Understanding sarcopenia at the single muscle cell level
Open accessAbstract
The loss of muscle mass with age, also known as sarcopenia, is a major scientific and public health problem. Muscle atrophy is associated with the loss of functional capacity and poor health outcomes in elderly men and women. A detailed understanding of this problem in humans can be enhanced by the use of experiments with single muscle fibers. It is likely that both muscle atrophy and a decrease in muscle-fiber quality contribute to muscle dysfunction among the elderly. A better understanding of sarcopenia at the single-fiber level may lead to the design of more effective rehabilitative interventions.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Sarcopenia is accompanied by diminished regenerative capacity due to loss in number and activity of satellite cells in type II fast fibers.
“These changes are also accompanied by a diminished regenerative capacity of the muscle due to a loss in the number and activity of satellite cells in type II “fast” fibers [14,16,17].”
From Potential Roles of n-3 PUFAs during Skeletal Muscle Growth and Regeneration (2018) · cites this paper as [16]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
The citation lists haven’t been fetched yet
References 19 · Cited by 108
- Authors
- Frontera, W. R., Rodriguez Zayas, A., & Rodriguez, N.
- Affiliations
- University of Puerto Rico, Medical Sciences Campus (PR)
- Corresponding author
- Frontera, Walter R.
- ORCID
- Frontera, Walter R.
- Venue
- Physical Medicine and Rehabilitation Clinics of North America
- Publisher
- Elsevier BV
- Published
- 2012-02
- Volume
- 23
- Issue
- 1
- Pages
- 201-207
- ISSN
- 1047-9651 (ISSN-L)
- PMC
- PMC3258429
- OpenAlex
- W2023009286
- Cited by
- 108
- References
- 19
- Citations by year
- 2026: 7 · 2025: 7 · 2024: 9 · 2023: 14 · 2022: 10 · 2021: 8 · 2020: 6 · 2019: 5 · 2018: 4 · 2017: 2 · 2016: 3 · 2015: 8 · 2014: 14 · 2013: 8 · 2012: 3
- FWCI
- 3.24
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Physical Medicine and Rehabilitation Clinics of North America (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (1u54rr026139-01a1)
- National Center for Research Resources (U54-RR026139)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
- Keywords
- sarcopenia, muscle aging, muscle atrophy, single muscle fibers, rehabilitation therapy
- MeSH terms
- Aging, Humans, Sex Factors, Muscle, Skeletal, Muscle Fibers, Skeletal, Muscle Weakness, Sarcopenia
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
