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Cognitive Impairment in Acquired Brain Injury: A Predictor of Rehabilitation Outcomes and an Opportunity for Novel Interventions
Open accessAbstract
Cognitive impairment is a common sequela in acquired brain injury and one that predicts rehabilitation outcomes. There is emerging evidence that impairments in cognitive functions can be manipulated by both pharmacologic and nonpharmacologic interventions to improve rehabilitation outcomes. By using stroke as a model for acquired brain injury, we review the evidence that links cognitive impairment to poor rehabilitation outcomes and discuss possible mechanisms to explain this association. Furthermore, we examine nascent promising research that suggests that interventions that target cognitive impairments can lead to better rehabilitation outcomes.
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Cognitive impairment can limit appropriate, flexible goal setting and behaviour, and mood disturbance can impact motivation which may reduce engagement in rehabilitation.
“For example, cognitive impairment can limit appropriate, flexible goal setting and behaviour, and mood disturbance can impact motivation which may reduce engagement in rehabilitation (Beadle et al., 2018;Kutlubaev & Hackett, 2014;Whyte et al., 2011).”
From A single-case experimental evaluation of a new group-based intervention to enhance adjustment to life with acquired brain injury: VaLiANT (valued living after neurological trauma) (2022) · cites this paper as Whyte et al., 2011
The ‘Adaptation’ and ‘Possible Pathways that Link Cognitive Function with Rehabilitation Outcomes’ sections explain how cognitive impairment can interfere with problem-solving, flexible responses, and participation in rehabilitation. The paper does not state that mood disturbance reduces engagement by affecting motivation; its References section lists related studies but does not establish that link. (LLM, conf=0.85)
Experimental — accuracy not yet measuredMood disturbance can impact motivation which may reduce engagement in rehabilitation.
“mood disturbance can impact motivation which may reduce engagement in rehabilitation”
From A single-case experimental evaluation of a new group-based intervention to enhance adjustment to life with acquired brain injury: VaLiANT (valued living after neurological trauma) (2022) · cites this paper as Whyte et al., 2011
The section “Possible Pathways that Link Cognitive Function with Rehabilitation Outcomes” says cognitive and executive-function impairments are associated with reduced participation in rehabilitation. The References list also names a study on depression and rehabilitation participation, but the paper does not state that mood disturbance reduces engagement by affecting motivation. No page number is available in our copy. (LLM, conf=0.72)
Experimental — accuracy not yet measuredCognitive impairment can limit appropriate, flexible goal setting and behaviour.
“cognitive impairment can limit appropriate, flexible goal setting and behaviour”
From A single-case experimental evaluation of a new group-based intervention to enhance adjustment to life with acquired brain injury: VaLiANT (valued living after neurological trauma) (2022) · cites this paper as Whyte et al., 2011
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Research works printed but not linked: 83
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Metadata
- Authors
- Whyte, E., Skidmore, E., Aizenstein, H., Ricker, J., & Butters, M.
- Affiliations
- National Institutes of Health (US)
- University of Pittsburgh (US)
- Corresponding author
- Whyte, Ellen
- Venue
- PM&R
- Publisher
- Wiley
- Published
- 2011-06
- Volume
- 3
- Issue
- 6S
- Pages
- S45-51
- ISSN
- 1934-1482 (ISSN-L)
- 1934-1563
- PMC
- PMC4492523
- OpenAlex
- W2082048642
- Cited by
- 60
- References
- 88
- Citations by year
- 2026: 5 · 2025: 2 · 2024: 4 · 2023: 4 · 2022: 5 · 2021: 8 · 2020: 4 · 2019: 5 · 2018: 4 · 2017: 5 · 2016: 4 · 2015: 4 · 2014: 2 · 2013: 2 · 2012: 2
- FWCI
- 0.23
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- PM&R (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (R44 NS 052948‐02A2)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury Research
- Health Sciences › Medicine › Rehabilitation › Stroke Rehabilitation and Recovery
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Functions and Memory
- Keywords
- cognitive impairment, acquired brain injury, stroke, rehabilitation outcomes, prognostic factors, pharmacological interventions, non-pharmacological treatment, cognitive rehabilitation
- MeSH terms
- Brain Injuries, Cognition Disorders, Humans, United States, Incidence, Prevalence, Disease Progression, Stroke
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